{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(23)"],"submitter":["Ravindran S"],"pubmed_abstract":["<b>Background/Objectives:</b> Asthma is a heterogeneous inflammatory airway disease. Periostin, a matricellular protein induced by interleukin-13, contributes to airway inflammation and remodeling. This study evaluated serum periostin as a diagnostic biomarker and explored multidimensional phenotypes in adult asthma. <b>Methods:</b> A cross-sectional study included 76 adults, with 25 healthy controls, 25 moderate, and 26 severe asthma patients, classified per Global Initiative for Asthma (GINA)-2020 guidelines. Serum periostin was measured using an enzyme-linked immunosorbent assay (ELISA). Diagnostic accuracy was assessed using receiver operating characteristic (ROC) analysis, Firth-penalized logistic regression, bootstrap calibration (1000 resamples), decision curve analysis (DCA), and g"],"journal":["Diagnostics (Basel, Switzerland)"],"pagination":["3028"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12691264"],"repository":["biostudies-literature"],"pubmed_title":["Unsupervised Phenotyping of Asthma: Integrating Serum Periostin with Clinical and Inflammatory Profiles."],"pmcid":["PMC12691264"],"pubmed_authors":["Ramaiah S","Chaya SK","Mahesh PA","Kaleem Ullah M","Shankar M","Kulkarni S","Parthasarathi A","Madhunapantula SV","ShankaraSetty RV","Siddaiah JB","Ravindran S","Greeshma MV","Bansal N","Karnik M","Lokesh KS","Srinivas S","Padmakaran V"],"additional_accession":[]},"is_claimable":false,"name":"Unsupervised Phenotyping of Asthma: Integrating Serum Periostin with Clinical and Inflammatory Profiles.","description":"<b>Background/Objectives:</b> Asthma is a heterogeneous inflammatory airway disease. Periostin, a matricellular protein induced by interleukin-13, contributes to airway inflammation and remodeling. This study evaluated serum periostin as a diagnostic biomarker and explored multidimensional phenotypes in adult asthma. <b>Methods:</b> A cross-sectional study included 76 adults, with 25 healthy controls, 25 moderate, and 26 severe asthma patients, classified per Global Initiative for Asthma (GINA)-2020 guidelines. Serum periostin was measured using an enzyme-linked immunosorbent assay (ELISA). Diagnostic accuracy was assessed using receiver operating characteristic (ROC) analysis, Firth-penalized logistic regression, bootstrap calibration (1000 resamples), decision curve analysis (DCA), and g","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-05-26T17:08:14.918Z","creation":"2026-05-24T03:11:21.48Z"},"accession":"S-EPMC12691264","cross_references":{"pubmed":["41374409"],"doi":["10.3390/diagnostics15233028"]}}