biostudies-literatureUnknown15(23)Ravindran S<b>Background/Objectives:</b> Asthma is a heterogeneous inflammatory airway disease. Periostin, a matricellular protein induced by interleukin-13, contributes to airway inflammation and remodeling. This study evaluated serum periostin as a diagnostic biomarker and explored multidimensional phenotypes in adult asthma. <b>Methods:</b> A cross-sectional study included 76 adults, with 25 healthy controls, 25 moderate, and 26 severe asthma patients, classified per Global Initiative for Asthma (GINA)-2020 guidelines. Serum periostin was measured using an enzyme-linked immunosorbent assay (ELISA). Diagnostic accuracy was assessed using receiver operating characteristic (ROC) analysis, Firth-penalized logistic regression, bootstrap calibration (1000 resamples), decision curve analysis (DCA), and gDiagnostics (Basel, Switzerland)3028https://www.ebi.ac.uk/biostudies/studies/S-EPMC12691264biostudies-literatureUnsupervised Phenotyping of Asthma: Integrating Serum Periostin with Clinical and Inflammatory Profiles.PMC12691264Ramaiah SChaya SKMahesh PAKaleem Ullah MShankar MKulkarni SParthasarathi AMadhunapantula SVShankaraSetty RVSiddaiah JBRavindran SGreeshma MVBansal NKarnik MLokesh KSSrinivas SPadmakaran VfalseUnsupervised Phenotyping of Asthma: Integrating Serum Periostin with Clinical and Inflammatory Profiles.<b>Background/Objectives:</b> Asthma is a heterogeneous inflammatory airway disease. Periostin, a matricellular protein induced by interleukin-13, contributes to airway inflammation and remodeling. This study evaluated serum periostin as a diagnostic biomarker and explored multidimensional phenotypes in adult asthma. <b>Methods:</b> A cross-sectional study included 76 adults, with 25 healthy controls, 25 moderate, and 26 severe asthma patients, classified per Global Initiative for Asthma (GINA)-2020 guidelines. Serum periostin was measured using an enzyme-linked immunosorbent assay (ELISA). Diagnostic accuracy was assessed using receiver operating characteristic (ROC) analysis, Firth-penalized logistic regression, bootstrap calibration (1000 resamples), decision curve analysis (DCA), and g2025-01-01T00:00:00Z2025 Nov2026-05-26T17:08:14.918Z2026-05-24T03:11:21.48ZS-EPMC126912644137440910.3390/diagnostics15233028