{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(12)"],"submitter":["Lou J"],"pubmed_abstract":["Porcine epidemic diarrhea virus (PEDV), an enteropathogenic coronavirus that causes severe intestinal disease in piglets, employs sophisticated strategies to subvert host antiviral immunity. While type III interferons (IFN-III) play a pivotal role in mucosal defense at intestinal epithelial barriers, the mechanisms underlying PEDV evasion of IFN-III signaling remain poorly understood. Given that peroxisomes serve as critical platforms for IFN-III signaling and that their abundance influences immune activation, we investigated the role of pexophagy in PEDV-mediated immune evasion. We demonstrated that the PEDV nonstructural protein NSP8 functions as a potent inhibitor of mitochondrial antiviral-signaling protein (MAVS)-dependent IFN-III production. Functional analyses revealed that NSP8 sig"],"journal":["mBio"],"pagination":["e0239625"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12691671"],"repository":["biostudies-literature"],"pubmed_title":["PEDV NSP8 inhibits IFN-III production induced by MAVS through downregulation of PEX13."],"pmcid":["PMC12691671"],"pubmed_authors":["Yang Z","Zhu H","Wang X","Lou J","Jiang P","Liu G"],"additional_accession":[]},"is_claimable":false,"name":"PEDV NSP8 inhibits IFN-III production induced by MAVS through downregulation of PEX13.","description":"Porcine epidemic diarrhea virus (PEDV), an enteropathogenic coronavirus that causes severe intestinal disease in piglets, employs sophisticated strategies to subvert host antiviral immunity. While type III interferons (IFN-III) play a pivotal role in mucosal defense at intestinal epithelial barriers, the mechanisms underlying PEDV evasion of IFN-III signaling remain poorly understood. Given that peroxisomes serve as critical platforms for IFN-III signaling and that their abundance influences immune activation, we investigated the role of pexophagy in PEDV-mediated immune evasion. We demonstrated that the PEDV nonstructural protein NSP8 functions as a potent inhibitor of mitochondrial antiviral-signaling protein (MAVS)-dependent IFN-III production. Functional analyses revealed that NSP8 sig","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-07T04:58:44.409Z","creation":"2026-06-07T03:07:35.095Z"},"accession":"S-EPMC12691671","cross_references":{"pubmed":["41186416"],"doi":["10.1128/mbio.02396-25"]}}