{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Davis BR"],"funding":["Howard Hughes Medical Institute","National Institutes of Health","NIH HHS"],"pagination":["e0226725"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12691682"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(12)"],"pubmed_abstract":["Animals defend against infections and other diseases by adaptively responding to the microbiota they encounter. These adaptations are driven by changes in gene expression programs; however, our understanding of the transcription factors regulating host responses to microbiota remains limited. By leveraging gene expression and chromatin accessibility data from zebrafish and mice, we identified the epithelial-specific E74-like ETS transcription factor 3 (<i>Elf3</i>) as a conserved microbially responsive transcription factor. Transcriptomic analysis of gnotobiotic <i>elf3</i> mutant zebrafish larvae revealed that <i>elf3</i> is required for a normal host response to microbiota, including induction of immune response genes. Mutation of <i>elf3</i> led to immune-related pathologies such as inf"],"journal":["mBio"],"pubmed_title":["Epithelial transcription factor Elf3 mediates host immune responses to microbiota and protects against aerocystitis in zebrafish."],"pmcid":["PMC12691682"],"funding_grant_id":["F30-DK135357","P01-DK0947","GT13485"],"pubmed_authors":["Morash M","Wen J","Lickwar CR","Tobin DM","Lohr CV","Moore PJ","Davis BR","Sweeney MI","Reich EL","Rawls JF"],"additional_accession":[]},"is_claimable":false,"name":"Epithelial transcription factor Elf3 mediates host immune responses to microbiota and protects against aerocystitis in zebrafish.","description":"Animals defend against infections and other diseases by adaptively responding to the microbiota they encounter. These adaptations are driven by changes in gene expression programs; however, our understanding of the transcription factors regulating host responses to microbiota remains limited. By leveraging gene expression and chromatin accessibility data from zebrafish and mice, we identified the epithelial-specific E74-like ETS transcription factor 3 (<i>Elf3</i>) as a conserved microbially responsive transcription factor. Transcriptomic analysis of gnotobiotic <i>elf3</i> mutant zebrafish larvae revealed that <i>elf3</i> is required for a normal host response to microbiota, including induction of immune response genes. Mutation of <i>elf3</i> led to immune-related pathologies such as inf","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-06T00:19:40.135Z","creation":"2026-05-23T03:14:09.705Z"},"accession":"S-EPMC12691682","cross_references":{"pubmed":["41147741"],"doi":["10.1128/mbio.02267-25"]}}