{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shi H"],"funding":["Key Research and Transformation Project of Science and Technology Department of Qinghai Province"],"pagination":["4039"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12691744"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(23)"],"pubmed_abstract":["Apples from high-altitude orchards exhibit a distinctive sugar-acid balance, yet the varietal and maturity drivers remain unclear. A multi-omics survey was conducted to map sugars and acids and to resolve pathway control. Chromatography-mass spectrometry, RNA-seq, and principal component (PC) dimensionality reduction fitting analysis were integrated across <i>Malus prunifolia</i> and <i>M. asiatica</i> at 60 and 120 days after flowering (DAF). PC separated maturity on PC1 and species on PC2, and canonical correlation confirmed gene-metabolite couplings. Malate predominated but declined with ripening as sucrose rose; <i>M. prunifolia</i> at 60 DAF showed higher maltose/inositol, whereas <i>M. asiatica</i> at 120 DAF accumulated pentoses/xylitol. In <i>M. prunifolia</i> 60 vs. 120 DAF (Q60-Q"],"journal":["Foods (Basel, Switzerland)"],"pubmed_title":["Integrative Multi-Omics Reveals Quality Markers and Metabolic Pathways Across Genotype and Ripening Gradients in High-Altitude &lt;i&gt;Malus&lt;/i&gt;."],"pmcid":["PMC12691744"],"funding_grant_id":["2023-NK-130"],"pubmed_authors":["Tian J","Li Y","Wei C","Guo T","Hou X","Shi H"],"additional_accession":[]},"is_claimable":false,"name":"Integrative Multi-Omics Reveals Quality Markers and Metabolic Pathways Across Genotype and Ripening Gradients in High-Altitude &lt;i&gt;Malus&lt;/i&gt;.","description":"Apples from high-altitude orchards exhibit a distinctive sugar-acid balance, yet the varietal and maturity drivers remain unclear. A multi-omics survey was conducted to map sugars and acids and to resolve pathway control. Chromatography-mass spectrometry, RNA-seq, and principal component (PC) dimensionality reduction fitting analysis were integrated across <i>Malus prunifolia</i> and <i>M. asiatica</i> at 60 and 120 days after flowering (DAF). PC separated maturity on PC1 and species on PC2, and canonical correlation confirmed gene-metabolite couplings. Malate predominated but declined with ripening as sucrose rose; <i>M. prunifolia</i> at 60 DAF showed higher maltose/inositol, whereas <i>M. asiatica</i> at 120 DAF accumulated pentoses/xylitol. In <i>M. prunifolia</i> 60 vs. 120 DAF (Q60-Q","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-05-26T14:05:41.797Z","creation":"2026-05-24T03:11:15.324Z"},"accession":"S-EPMC12691744","cross_references":{"pubmed":["41375977"],"doi":["10.3390/foods14234039"]}}