{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rivera JC"],"funding":["NIMHD NIH HHS","California TRDRP","NIMHD AXIS","NIH R25","NIGMS NIH HHS","DOD CDMRP"],"pagination":["11491"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12691771"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(23)"],"pubmed_abstract":["Electronic cigarettes (E-Cig) are a new way of delivering nicotine, gaining popularity among adolescents and young adults, who often do not realize their harmful effects. Although the adverse effects of E-Cigs on the liver and heart have been demonstrated, their effects on the skeletal muscle have not been well studied. In this study, we evaluated the skeletal muscle effects of E-Cig aerosol, delivered in a manner similar to human vaping, in a mouse model of obesity induced by a high-fat diet (HFD). C57BL/6 mice, fed either a normal chow diet (NCD) or HFD, were exposed to either saline aerosol control or aerosol generated from Blu PLUS<sup>TM</sup> containing 0% or 2.4% nicotine for 12 weeks. Mice fed an NCD were included to distinguish whether E-Cig effects on the skeletal muscle required"],"journal":["International journal of molecular sciences"],"pubmed_title":["Electronic Cigarette Exposure Induces Adverse Cellular Alterations in Skeletal Muscle in Male Mice Subjected to a High-Fat Diet."],"pmcid":["PMC12691771"],"funding_grant_id":["28CP-0040","SC2GM125551","DA050723","PR190942","S21-MD000103","U54MD007598","SC2GM135127"],"pubmed_authors":["Wilson J","Tintut Y","Jordan MC","Sinha-Hikim AP","Friedman TC","Liu Y","Shao XM","Rivera JC","Espinoza-Derout J","Lao CJ","Hasan K","Puri V","Roos KP"],"additional_accession":[]},"is_claimable":false,"name":"Electronic Cigarette Exposure Induces Adverse Cellular Alterations in Skeletal Muscle in Male Mice Subjected to a High-Fat Diet.","description":"Electronic cigarettes (E-Cig) are a new way of delivering nicotine, gaining popularity among adolescents and young adults, who often do not realize their harmful effects. Although the adverse effects of E-Cigs on the liver and heart have been demonstrated, their effects on the skeletal muscle have not been well studied. In this study, we evaluated the skeletal muscle effects of E-Cig aerosol, delivered in a manner similar to human vaping, in a mouse model of obesity induced by a high-fat diet (HFD). C57BL/6 mice, fed either a normal chow diet (NCD) or HFD, were exposed to either saline aerosol control or aerosol generated from Blu PLUS<sup>TM</sup> containing 0% or 2.4% nicotine for 12 weeks. Mice fed an NCD were included to distinguish whether E-Cig effects on the skeletal muscle required","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-05-26T17:06:14.312Z","creation":"2026-05-24T03:11:15.678Z"},"accession":"S-EPMC12691771","cross_references":{"pubmed":["41373646"],"doi":["10.3390/ijms262311491"]}}