biostudies-literatureWang QNational Natural Science Foundation of China3998https://www.ebi.ac.uk/biostudies/studies/S-EPMC12691872biostudies-literatureUnknown14(23)A three-dimensional Ag/TiO<sub>2</sub>/Ti foam was fabricated via thermal annealing followed by pulsed laser deposition (PLD), providing a simple and scalable fabrication strategy. The porous Ti foam framework allows for the uniform dispersion of Ag nanoparticles (NPs), while the thermally formed TiO<sub>2</sub> interlayer promotes synergistic electromagnetic and chemical enhancement mechanisms. The localized electromagnetic field amplification at Ag-TiO<sub>2</sub> interfaces was simulated using the finite-difference time-domain (FDTD) method. Density functional theory (DFT) calculations confirmed that TiO<sub>2</sub> enhances both rhodamine 6G (R6G) adsorption on the substrate and charge transfer (CT) between the substrate and R6G, increasing the SERS activity. The optimized substrate deFoods (Basel, Switzerland)Highly Sensitive SERS Detection of Food Colorants via Charge Transfer of Metal and Semiconductor in Ag/TiO<sub>2</sub>/Ti Foam.PMC1269187222273066Jing YSui SWang QWang RZhang JChen LZhangWang XfalseHighly Sensitive SERS Detection of Food Colorants via Charge Transfer of Metal and Semiconductor in Ag/TiO<sub>2</sub>/Ti Foam.A three-dimensional Ag/TiO<sub>2</sub>/Ti foam was fabricated via thermal annealing followed by pulsed laser deposition (PLD), providing a simple and scalable fabrication strategy. The porous Ti foam framework allows for the uniform dispersion of Ag nanoparticles (NPs), while the thermally formed TiO<sub>2</sub> interlayer promotes synergistic electromagnetic and chemical enhancement mechanisms. The localized electromagnetic field amplification at Ag-TiO<sub>2</sub> interfaces was simulated using the finite-difference time-domain (FDTD) method. Density functional theory (DFT) calculations confirmed that TiO<sub>2</sub> enhances both rhodamine 6G (R6G) adsorption on the substrate and charge transfer (CT) between the substrate and R6G, increasing the SERS activity. The optimized substrate de2025-01-01T00:00:00Z2025 Nov2026-05-26T11:01:09.852Z2026-05-24T03:11:22.151ZS-EPMC126918724137593610.3390/foods14233998