{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["26(23)"],"submitter":["Park BO"],"pubmed_abstract":["Extracellular vesicles (EVs) derived from probiotic bacteria have recently emerged as postbiotic mediators that regulate host cellular responses. This study investigated the effects of EVs from <i>Lactobacillus rhamnosus BS-Pro-08</i>, isolated from kefir grains (Lacto EV), on adipocyte differentiation and lipid metabolism. Lacto EV treatment markedly suppressed the differentiation of 3T3-L1 preadipocytes into mature adipocytes, as reflected by reduced lipid accumulation and decreased expression of the adipogenic transcription factors peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer-binding protein α (C/EBPα). This inhibitory effect was most pronounced at the early stage of adipogenesis. In mature adipocytes, Lacto EV enhanced lipolysis in a dose-dependent manner, ac"],"journal":["International journal of molecular sciences"],"pagination":["11732"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12692708"],"repository":["biostudies-literature"],"pubmed_title":["Extracellular Vesicles from &lt;i&gt;Lactobacillus rhamnosus BS-Pro-08&lt;/i&gt;, Kefir Grain, Suppress Adipogenesis and Enhance Lipolysis in Adipocytes."],"pmcid":["PMC12692708"],"pubmed_authors":["Shin S","Park BO","Sim J","Jung E","Yeom M","Wang H","Song CH","Lee HW","Cho E","Park D"],"additional_accession":[]},"is_claimable":false,"name":"Extracellular Vesicles from &lt;i&gt;Lactobacillus rhamnosus BS-Pro-08&lt;/i&gt;, Kefir Grain, Suppress Adipogenesis and Enhance Lipolysis in Adipocytes.","description":"Extracellular vesicles (EVs) derived from probiotic bacteria have recently emerged as postbiotic mediators that regulate host cellular responses. This study investigated the effects of EVs from <i>Lactobacillus rhamnosus BS-Pro-08</i>, isolated from kefir grains (Lacto EV), on adipocyte differentiation and lipid metabolism. Lacto EV treatment markedly suppressed the differentiation of 3T3-L1 preadipocytes into mature adipocytes, as reflected by reduced lipid accumulation and decreased expression of the adipogenic transcription factors peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer-binding protein α (C/EBPα). This inhibitory effect was most pronounced at the early stage of adipogenesis. In mature adipocytes, Lacto EV enhanced lipolysis in a dose-dependent manner, ac","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-05-26T14:05:54.592Z","creation":"2026-05-24T03:11:13.555Z"},"accession":"S-EPMC12692708","cross_references":{"pubmed":["41373877"],"doi":["10.3390/ijms262311732"]}}