{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li W"],"funding":["Jiangxi Provincial Natural Science Foundation"],"pagination":["3133"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12694446"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(23)"],"pubmed_abstract":["Aligned fibrous scaffolds are essential for directing soft-tissue regeneration, yet synthetic polymers lack native biochemical cues. To bridge this gap, bioactive and anisotropic scaffolds were developed by combining melt electrowriting (MEW) with decellularized extracellular matrix (dECM) decoration to enhance cell-scaffold interactions for soft tissue engineering. Porous polycaprolactone (PCL) scaffolds with aligned microfibers and tunable pore architectures (aspect ratios 1:1, 1:2, and 1:3) were fabricated via MEW and subsequently coated with porcine skeletal muscle dECM using a dip-gelation method. Comprehensive surface characterization confirmed the presence and robust adhesion of the dECM coating on the PCL scaffolds, which concurrently enhanced surface hydrophilicity. Furthermore, m"],"journal":["Polymers"],"pubmed_title":["Modulating Cell-Scaffold Interaction via dECM-Decorated Melt Electrowriting PCL Scaffolds."],"pmcid":["PMC12694446"],"funding_grant_id":["20252BAC240571"],"pubmed_authors":["Li W","Gao X","Zhang P"],"additional_accession":[]},"is_claimable":false,"name":"Modulating Cell-Scaffold Interaction via dECM-Decorated Melt Electrowriting PCL Scaffolds.","description":"Aligned fibrous scaffolds are essential for directing soft-tissue regeneration, yet synthetic polymers lack native biochemical cues. To bridge this gap, bioactive and anisotropic scaffolds were developed by combining melt electrowriting (MEW) with decellularized extracellular matrix (dECM) decoration to enhance cell-scaffold interactions for soft tissue engineering. Porous polycaprolactone (PCL) scaffolds with aligned microfibers and tunable pore architectures (aspect ratios 1:1, 1:2, and 1:3) were fabricated via MEW and subsequently coated with porcine skeletal muscle dECM using a dip-gelation method. Comprehensive surface characterization confirmed the presence and robust adhesion of the dECM coating on the PCL scaffolds, which concurrently enhanced surface hydrophilicity. Furthermore, m","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-05-26T11:09:01.97Z","creation":"2026-05-24T03:11:30.817Z"},"accession":"S-EPMC12694446","cross_references":{"pubmed":["41374820"],"doi":["10.3390/polym17233133"]}}