biostudies-literatureShih CIKaohsiung Medical UniversityKaohsiung Medical University, Kaohsiung Medical University Chun-Ho Memorial HospitalThe Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in TaiwanCenter of Excellence for Metabolic Associated Fatty Liver Disease, National Sun Yat-sen UniversityTaiwan Liver Research FoundationCenter for Metabolic Disorders and Obesitye70077https://www.ebi.ac.uk/biostudies/studies/S-EPMC12694567biostudies-literatureUnknown41(12)This study investigates the impact of cardiometabolic risk factors (CMRF) on the prevalence and incidence of hypertension (HTN) and diabetes mellitus (DM) in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) and nonsteatotic liver disease (non-SLD), using both cross-sectional and longitudinal data. A total of 32,569 Taiwanese adults without viral hepatitis or significant alcohol consumption who underwent health checkups from 1999 to 2013 were analyzed cross-sectionally. Among them, 27,109 individuals free of HTN and DM at baseline and within 1 year of enrollment were followed longitudinally. Participants were classified into four groups based on hepatic steatosis assessed by ultrasound and presence of CMRF: healthy control (non-SLD/CMRF-), simple SLD (SLD/CMThe Kaohsiung journal of medical sciencesDynamics of Cardiometabolic Risk Factors Are Linked to the Risk of Hypertension and Diabetes in MASLD.PMC12694567KMHK-DK(C)111004NYCUKMU‐111‐I00MOHW112-TDU-B-221-124007NYCUKMU‐111‐I004MHK-DK(C)111006NSTC 112‐2321‐B‐001‐006NYCUKMU-111-I00KMHK‐DK(C)111004KMU-TC114A08NYCUKMU-111-I004MOHW112‐TDU‐B‐221‐124007NSTC 112-2321-B-001-006MHK‐DK(C)111006Wei YJTsai PCShih PTShih CIHsieh MYHuang CFHo CKChen YYCheng YYWang CWChang WTLin YHWu KTChuang WLYang JFWong VWHsieh MHYu MLDai CYYeh MLLiang PCHuang JFfalseDynamics of Cardiometabolic Risk Factors Are Linked to the Risk of Hypertension and Diabetes in MASLD.This study investigates the impact of cardiometabolic risk factors (CMRF) on the prevalence and incidence of hypertension (HTN) and diabetes mellitus (DM) in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) and nonsteatotic liver disease (non-SLD), using both cross-sectional and longitudinal data. A total of 32,569 Taiwanese adults without viral hepatitis or significant alcohol consumption who underwent health checkups from 1999 to 2013 were analyzed cross-sectionally. Among them, 27,109 individuals free of HTN and DM at baseline and within 1 year of enrollment were followed longitudinally. Participants were classified into four groups based on hepatic steatosis assessed by ultrasound and presence of CMRF: healthy control (non-SLD/CMRF-), simple SLD (SLD/CM2025-01-01T00:00:00Z2025 Dec2026-06-06T00:29:32.973Z2026-05-24T03:11:37.956ZS-EPMC126945674065066810.1002/kjm2.70077