{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Koubassova NA"],"funding":["National Institute of Arthritis and Musculoskeletal and Skin Diseases","National Institute of Allergy and Infectious Diseases","NHLBI NIH HHS","Empire State Development Corporation","National Institutes of Health","National Heart Lung and Blood Institute","NIAMS NIH HHS","National Institute of General Medical Sciences","NIGMS NIH HHS","National Science Foundation"],"pagination":["3663-3677"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12694897"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["124(21)"],"pubmed_abstract":["Low-angle x-ray diffraction is a powerful technique for analyzing the molecular structure of the myofilaments of striated muscle in situ. It has contributed greatly to our understanding of the relaxed, 430-Å repeating organization of myosin heads in thick filaments in skeletal and cardiac muscle. Using x-ray diffraction, changes in filament structure can be detected on the angstrom length scale and millisecond timescale, leading to models that are the foundation of our understanding of the structural basis of contraction. As with all x-ray fiber diffraction studies, interpretation requires modeling, which has previously been based on low-resolution knowledge of thick filament structure and is complicated by the contributions of multiple filament components to most x-ray reflections. Here, "],"journal":["Biophysical journal"],"pubmed_title":["Annotating the x-ray diffraction pattern of vertebrate striated muscle."],"pmcid":["PMC12694897"],"funding_grant_id":["R01 GM129325","DMR-1829070","P30 GM124166","GM129325","AR072036","R01 AR081941","1-P30-GM124166-01A1","R01 AR072036","P30 GM138395","R01 HL164560","HL139883","R01 HL139883","HL164560","AR081941"],"pubmed_authors":["Craig R","Dutta D","Tsaturyan AK","Padron R","Koubassova NA","Irving T","Ma W"],"additional_accession":[]},"is_claimable":false,"name":"Annotating the x-ray diffraction pattern of vertebrate striated muscle.","description":"Low-angle x-ray diffraction is a powerful technique for analyzing the molecular structure of the myofilaments of striated muscle in situ. It has contributed greatly to our understanding of the relaxed, 430-Å repeating organization of myosin heads in thick filaments in skeletal and cardiac muscle. Using x-ray diffraction, changes in filament structure can be detected on the angstrom length scale and millisecond timescale, leading to models that are the foundation of our understanding of the structural basis of contraction. As with all x-ray fiber diffraction studies, interpretation requires modeling, which has previously been based on low-resolution knowledge of thick filament structure and is complicated by the contributions of multiple filament components to most x-ray reflections. Here, ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-07T05:08:22.792Z","creation":"2026-06-07T03:07:15.79Z"},"accession":"S-EPMC12694897","cross_references":{"pubmed":["40954998"],"doi":["10.1016/j.bpj.2025.09.019"]}}