{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["64(SI)"],"submitter":["Roth E"],"funding":["Foundation for Research in Rheumatology","Boehringer Ingelheim","AbbVie","Wellcome Trust"],"pubmed_abstract":["<h4>Objectives</h4>Gastroesophageal reflux disease (GERD) is frequent in systemic sclerosis (SSc) and could predict progression of interstitial lung disease (ILD). We aimed to analyse (1) the prevalence of GERD among SSc-ILD patients, (2) its association with disease characteristics and (3) predictive factors for ILD progression in SSc-ILD patients with GERD.<h4>Methods</h4>SSc patients from the EUSTAR database with ILD were included. GERD was labelled as present if reflux/dysphagia was reported at the baseline visit or before. Disease characteristics of patients with and without GERD were compared at baseline. ILD progression was defined as relative FVC decline ≥10% or relative FVC decline between 5-9% in association with relative DLCO decline of ≥15% over 12 ± 3 months of follow-up. Prog"],"journal":["Rheumatology (Oxford, England)"],"pagination":["SI63-SI72"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12695048"],"repository":["biostudies-literature"],"pubmed_title":["Gastroesophageal reflux disease is associated with a more severe interstitial lung disease in systemic sclerosis in the EUSTAR cohort."],"pmcid":["PMC12695048"],"pubmed_authors":["Govind N","Motta F","Rudnicka L","Kubacki T","Kawaguchi Y","Agarbati S","Montecucco C","Vonk M","Becker MO","Knaapen H","Foti R","Elhai M","Chaigne B","Pitarch BA","Vanthuyne M","Giacomelli R","Kerzberg E","Levy Y","Majewski D","Mihai C","Agachi S","Muraru S","Riccieri V","Thurlings R","Walker U","Bruni C","Allanore Y","Masato O","Novak S","Matucci-Cerinic M","Benvenuti F","Iagnocco A","Voigt K","Visevic R","Mitrovic J","Kuwana M","Engelhart M","Granel B","Bianchi BV","Litinsky I","Moiseev S","Tanaseanu CM","Ingegnoli F","Stamenkovic B","Cantatore FP","Garmish O","Idolazzi L","Santos L","Mosca M","Del Galdo F","Mukuchyan V","Karadag DT","Petelytska L","Muller-Ladner U","Auth J","De Langhe E","Ribi C","Lauffer F","Ickinger C","Fathi N","Senet P","Rodrigues AC","Iudici M","Gerth U","Green L","Cordeiro A","Poormoghim H","Maurer B","Rosato E","Selvi E","Olesinska M","Boleto G","De Araujo DB","Garen T","Couto M","Carreira PE","Hunzelmann N","Hsu VM","Bazela-Ostromecka A","Adler S","Sondergaard K","Ginosyan K","Schmeiser T","Henes J","Solanki K","Yavuz S","Kakkar V","Geneva-Popova M","Nunag A","Guiducci S","Bajocchi G","Atzeni F","Aringer M","Ramsli MT","Lescoat A","Soukup T","Inanc M","Santos CIS","Hoffmann-Vold AM","Ananieva LP","Vlachoyiannopoulos P","Khanna D","Shah AA","Radic M","Braun-Moscovici Y","Huizinga TWJ","Cuomo G","Fretheim H","Jordan S","Krasowska D","Mohamed WAAA","Liakouli V","Parvu M","Siegert E","Yasuoka H","Batalov A","Balanescu A","Wirsching A","Iwata F","Foeldvari I","Talotta R","Oliveira S","Vardanyan V","De Vries-Bouwstra J","Mamani M","Ong V","Mendez C","Seskute G","Ramming A","Veale D","Dunogue B","Wojteczek A","Martinez-Barrio J","Cauli A","Bongiovanni S","Rubeli S","Wiland P","Distler O","Naffaa M","Rimar D","Del Papa N","Bielecka OK","Hughes M","Spierings J","Szucs G","Joven B","Ani B","Martin M","Koenig M","Martin T","Coleiro B","Rodriguez-Pinto I","Mouthon L","Atsumi T","Stebbings S","Kastrati K","Gheorghiu AM","Tonutti A","Conde AN","Bergmann C","Kahl S","Markus J","Riemekasten G","Scherer HU","Dobrota R","Kohm M","Furst D","Maglio C","Zhini FY","Becvar R","Limonta M","Roth E","Benfaremo D","Rezus E","Lazaro E","Tanaka Y","Bancel DF","Ciccia F","Perdan-Pirkmajer K","Klemm P","van Leuven S","Sfikakis P","Senecal JL","Sokka-Isler T","Brzosko M","Pflugfelder J","EUSTAR Collaborators","Kotyla P","Ishii T","Epis OM","Moroncini G","Andreasson K","Balbir-Gurman A","Vacca A","Sampaio-Barros PD","Aznar CS","Mogensen M","Mekinian A","Kayser C","Svegliati S","Alegre-Sancho JJ","Cutolo M","de la Puente C","Pileckyte M","Tharwat S","Bernardino V","Airo P","Zanatta E","Blaise S","Geroldinger-Simic M","Kartalcik H","Ortiz-Santamaria V","Harty L","von Muhlen CA","Truchetet ME","Midtvedt O","Launay D","Rednic S","Hinchcliff M","Denton CP","Olas J","Cheema R","Castellvi I","Kumanovics G","Shimol JB","Kotter I","Milas-Ahic J","Chatelus E","Marcoccia A","Iannone F","Paolini C","Monaco AL","Loyo E","Ramazan AM","De Santis M","Chung LS","Hoa S","Haroyan A","Colic J","Martin JJG","de Souza Muller C","Di Donato S","Saketkoo LA","Smith V","Dzhus M","da Silva JAP","Ancuta C"],"additional_accession":[]},"is_claimable":false,"name":"Gastroesophageal reflux disease is associated with a more severe interstitial lung disease in systemic sclerosis in the EUSTAR cohort.","description":"<h4>Objectives</h4>Gastroesophageal reflux disease (GERD) is frequent in systemic sclerosis (SSc) and could predict progression of interstitial lung disease (ILD). We aimed to analyse (1) the prevalence of GERD among SSc-ILD patients, (2) its association with disease characteristics and (3) predictive factors for ILD progression in SSc-ILD patients with GERD.<h4>Methods</h4>SSc patients from the EUSTAR database with ILD were included. GERD was labelled as present if reflux/dysphagia was reported at the baseline visit or before. Disease characteristics of patients with and without GERD were compared at baseline. ILD progression was defined as relative FVC decline ≥10% or relative FVC decline between 5-9% in association with relative DLCO decline of ≥15% over 12 ± 3 months of follow-up. Prog","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-05-26T14:08:03.558Z","creation":"2026-05-24T03:11:19.513Z"},"accession":"S-EPMC12695048","cross_references":{"pubmed":["39775478"],"doi":["10.1093/rheumatology/keaf016"]}}