biostudies-literatureUnknown64(SI)Roth EFoundation for Research in RheumatologyBoehringer IngelheimAbbVieWellcome Trust<h4>Objectives</h4>Gastroesophageal reflux disease (GERD) is frequent in systemic sclerosis (SSc) and could predict progression of interstitial lung disease (ILD). We aimed to analyse (1) the prevalence of GERD among SSc-ILD patients, (2) its association with disease characteristics and (3) predictive factors for ILD progression in SSc-ILD patients with GERD.<h4>Methods</h4>SSc patients from the EUSTAR database with ILD were included. GERD was labelled as present if reflux/dysphagia was reported at the baseline visit or before. Disease characteristics of patients with and without GERD were compared at baseline. ILD progression was defined as relative FVC decline ≥10% or relative FVC decline between 5-9% in association with relative DLCO decline of ≥15% over 12 ± 3 months of follow-up. ProgRheumatology (Oxford, England)SI63-SI72https://www.ebi.ac.uk/biostudies/studies/S-EPMC12695048biostudies-literatureGastroesophageal reflux disease is associated with a more severe interstitial lung disease in systemic sclerosis in the EUSTAR cohort.PMC12695048Govind NMotta FRudnicka LKubacki TKawaguchi YAgarbati SMontecucco CVonk MBecker MOKnaapen HFoti RElhai MChaigne BPitarch BAVanthuyne MGiacomelli RKerzberg ELevy YMajewski DMihai CAgachi SMuraru SRiccieri VThurlings RWalker UBruni CAllanore YMasato ONovak SMatucci-Cerinic MBenvenuti FIagnocco AVoigt KVisevic RMitrovic JKuwana MEngelhart MGranel BBianchi BVLitinsky IMoiseev STanaseanu CMIngegnoli FStamenkovic BCantatore FPGarmish OIdolazzi LSantos LMosca MDel Galdo FMukuchyan VKaradag DTPetelytska LMuller-Ladner UAuth JDe Langhe ERibi CLauffer FIckinger CFathi NSenet PRodrigues ACIudici MGerth UGreen LCordeiro APoormoghim HMaurer BRosato ESelvi EOlesinska MBoleto GDe Araujo DBGaren TCouto MCarreira PEHunzelmann NHsu VMBazela-Ostromecka AAdler SSondergaard KGinosyan KSchmeiser THenes JSolanki KYavuz SKakkar VGeneva-Popova MNunag AGuiducci SBajocchi GAtzeni FAringer MRamsli MTLescoat ASoukup TInanc MSantos CISHoffmann-Vold AMAnanieva LPVlachoyiannopoulos PKhanna DShah AARadic MBraun-Moscovici YHuizinga TWJCuomo GFretheim HJordan SKrasowska DMohamed WAAALiakouli VParvu MSiegert EYasuoka HBatalov ABalanescu AWirsching AIwata FFoeldvari ITalotta ROliveira SVardanyan VDe Vries-Bouwstra JMamani MOng VMendez CSeskute GRamming AVeale DDunogue BWojteczek AMartinez-Barrio JCauli ABongiovanni SRubeli SWiland PDistler ONaffaa MRimar DDel Papa NBielecka OKHughes MSpierings JSzucs GJoven BAni BMartin MKoenig MMartin TColeiro BRodriguez-Pinto IMouthon LAtsumi TStebbings SKastrati KGheorghiu AMTonutti AConde ANBergmann CKahl SMarkus JRiemekasten GScherer HUDobrota RKohm MFurst DMaglio CZhini FYBecvar RLimonta MRoth EBenfaremo DRezus ELazaro ETanaka YBancel DFCiccia FPerdan-Pirkmajer KKlemm Pvan Leuven SSfikakis PSenecal JLSokka-Isler TBrzosko MPflugfelder JEUSTAR CollaboratorsKotyla PIshii TEpis OMMoroncini GAndreasson KBalbir-Gurman AVacca ASampaio-Barros PDAznar CSMogensen MMekinian AKayser CSvegliati SAlegre-Sancho JJCutolo Mde la Puente CPileckyte MTharwat SBernardino VAiro PZanatta EBlaise SGeroldinger-Simic MKartalcik HOrtiz-Santamaria VHarty Lvon Muhlen CATruchetet MEMidtvedt OLaunay DRednic SHinchcliff MDenton CPOlas JCheema RCastellvi IKumanovics GShimol JBKotter IMilas-Ahic JChatelus EMarcoccia AIannone FPaolini CMonaco ALLoyo ERamazan AMDe Santis MChung LSHoa SHaroyan AColic JMartin JJGde Souza Muller CDi Donato SSaketkoo LASmith VDzhus Mda Silva JAPAncuta CfalseGastroesophageal reflux disease is associated with a more severe interstitial lung disease in systemic sclerosis in the EUSTAR cohort.<h4>Objectives</h4>Gastroesophageal reflux disease (GERD) is frequent in systemic sclerosis (SSc) and could predict progression of interstitial lung disease (ILD). We aimed to analyse (1) the prevalence of GERD among SSc-ILD patients, (2) its association with disease characteristics and (3) predictive factors for ILD progression in SSc-ILD patients with GERD.<h4>Methods</h4>SSc patients from the EUSTAR database with ILD were included. GERD was labelled as present if reflux/dysphagia was reported at the baseline visit or before. Disease characteristics of patients with and without GERD were compared at baseline. ILD progression was defined as relative FVC decline ≥10% or relative FVC decline between 5-9% in association with relative DLCO decline of ≥15% over 12 ± 3 months of follow-up. Prog2025-01-01T00:00:00Z2025 Dec2026-05-26T14:08:03.558Z2026-05-24T03:11:19.513ZS-EPMC126950483977547810.1093/rheumatology/keaf016