{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shi H"],"funding":["NICHD NIH HHS","NIAID NIH HHS","NHLBI NIH HHS","NIGMS NIH HHS"],"pagination":["1799-1812"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12695087"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["44(8)"],"pubmed_abstract":["<h4>Background</h4>Integrin-regulated monocyte recruitment and cellular responses of monocyte-derived macrophages are critical for the pathogenesis of atherosclerosis. In the canonical model, talin1 controls ligand binding to integrins, a prerequisite for integrins to mediate leukocyte recruitment and induce immune responses. However, the role of talin1 in the development of atherosclerosis has not been studied. Our study investigated how talin1 in myeloid cells regulates the progression of atherosclerosis.<h4>Methods</h4>On an <i>Apoe</i><sup><i>-/-</i></sup> background, myeloid talin1-deficient mice and the control mice were fed with a high-fat diet for 8 or 12 weeks to induce atherosclerosis. The atherosclerosis development in the aorta and monocyte recruitment into atherosclerotic lesi"],"journal":["Arteriosclerosis, thrombosis, and vascular biology"],"pubmed_title":["Deletion of Talin1 in Myeloid Cells Facilitates Atherosclerosis in Mice."],"pmcid":["PMC12695087"],"funding_grant_id":["R35 HL144605","R01 HL149860","P30 GM114731","R21 AI171525","R01 HL153728","R01 HD083418","R01 HL128390"],"pubmed_authors":["Yao L","Zhou M","McGee S","McDaniel M","Shao B","Song J","Panicker SR","Shan X","Xia L","Gao L","Griffin CT","Zhong H","Shi H"],"additional_accession":[]},"is_claimable":false,"name":"Deletion of Talin1 in Myeloid Cells Facilitates Atherosclerosis in Mice.","description":"<h4>Background</h4>Integrin-regulated monocyte recruitment and cellular responses of monocyte-derived macrophages are critical for the pathogenesis of atherosclerosis. In the canonical model, talin1 controls ligand binding to integrins, a prerequisite for integrins to mediate leukocyte recruitment and induce immune responses. However, the role of talin1 in the development of atherosclerosis has not been studied. Our study investigated how talin1 in myeloid cells regulates the progression of atherosclerosis.<h4>Methods</h4>On an <i>Apoe</i><sup><i>-/-</i></sup> background, myeloid talin1-deficient mice and the control mice were fed with a high-fat diet for 8 or 12 weeks to induce atherosclerosis. The atherosclerosis development in the aorta and monocyte recruitment into atherosclerotic lesi","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-06-06T00:22:42.143Z","creation":"2026-05-23T03:14:15.863Z"},"accession":"S-EPMC12695087","cross_references":{"pubmed":["38899470"],"doi":["10.1161/ATVBAHA.123.319677","10.1161/atvbaha.123.319677"]}}