{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Geng J"],"pubmed_abstract":["<h4>Introduction</h4>Hyperlipidemia poses a serious threat to human health. However, given the significant adverse effect of drug therapy, finding safe and efficient lipid-lowering agents has become a focal point of interest. <i>Polygonatum sibiricum</i> Huangjiu (PSHJ) is hypothesized to exert lipid-lowering effects. This study examined PSHJ's ability to alleviate hyperlipidemia in mice caused by a high-fat diet, and the regulatory mechanism was studied via gut microbiome and fecal lipidomics.<h4>Methods</h4>A mouse model of hyperlipidemia was established using a high-fat diet. The experimental groups were administered PSHJ, and serum lipid profiles-including triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol ("],"journal":["Frontiers in nutrition"],"pagination":["1705061"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12695534"],"repository":["biostudies-literature"],"pubmed_title":["Multi-omics techniques revealing the mechanism of &lt;i&gt;Polygonatum sibiricum&lt;/i&gt; Huangjiu in alleviating hyperlipidemia in mice."],"pmcid":["PMC12695534"],"pubmed_authors":["Zhang G","Tian H","Dong J","Geng J","Lou Z"],"additional_accession":[]},"is_claimable":false,"name":"Multi-omics techniques revealing the mechanism of &lt;i&gt;Polygonatum sibiricum&lt;/i&gt; Huangjiu in alleviating hyperlipidemia in mice.","description":"<h4>Introduction</h4>Hyperlipidemia poses a serious threat to human health. However, given the significant adverse effect of drug therapy, finding safe and efficient lipid-lowering agents has become a focal point of interest. <i>Polygonatum sibiricum</i> Huangjiu (PSHJ) is hypothesized to exert lipid-lowering effects. This study examined PSHJ's ability to alleviate hyperlipidemia in mice caused by a high-fat diet, and the regulatory mechanism was studied via gut microbiome and fecal lipidomics.<h4>Methods</h4>A mouse model of hyperlipidemia was established using a high-fat diet. The experimental groups were administered PSHJ, and serum lipid profiles-including triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-06T02:23:54.837Z","creation":"2026-05-24T03:12:56.478Z"},"accession":"S-EPMC12695534","cross_references":{"pubmed":["41393931"],"doi":["10.3389/fnut.2025.1705061"]}}