biostudies-literatureUnknown12Geng J<h4>Introduction</h4>Hyperlipidemia poses a serious threat to human health. However, given the significant adverse effect of drug therapy, finding safe and efficient lipid-lowering agents has become a focal point of interest. <i>Polygonatum sibiricum</i> Huangjiu (PSHJ) is hypothesized to exert lipid-lowering effects. This study examined PSHJ's ability to alleviate hyperlipidemia in mice caused by a high-fat diet, and the regulatory mechanism was studied via gut microbiome and fecal lipidomics.<h4>Methods</h4>A mouse model of hyperlipidemia was established using a high-fat diet. The experimental groups were administered PSHJ, and serum lipid profiles-including triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (Frontiers in nutrition1705061https://www.ebi.ac.uk/biostudies/studies/S-EPMC12695534biostudies-literatureMulti-omics techniques revealing the mechanism of <i>Polygonatum sibiricum</i> Huangjiu in alleviating hyperlipidemia in mice.PMC12695534Zhang GTian HDong JGeng JLou ZfalseMulti-omics techniques revealing the mechanism of <i>Polygonatum sibiricum</i> Huangjiu in alleviating hyperlipidemia in mice.<h4>Introduction</h4>Hyperlipidemia poses a serious threat to human health. However, given the significant adverse effect of drug therapy, finding safe and efficient lipid-lowering agents has become a focal point of interest. <i>Polygonatum sibiricum</i> Huangjiu (PSHJ) is hypothesized to exert lipid-lowering effects. This study examined PSHJ's ability to alleviate hyperlipidemia in mice caused by a high-fat diet, and the regulatory mechanism was studied via gut microbiome and fecal lipidomics.<h4>Methods</h4>A mouse model of hyperlipidemia was established using a high-fat diet. The experimental groups were administered PSHJ, and serum lipid profiles-including triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (2025-01-01T00:00:00Z20252026-06-06T02:23:54.837Z2026-05-24T03:12:56.478ZS-EPMC126955344139393110.3389/fnut.2025.1705061