{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bents SJ"],"funding":["NIAID NIH HHS","Wellcome Trust"],"pagination":["11015"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12695953"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["The rebound of endemic respiratory viruses following the COVID-19 pandemic was marked by atypical transmission dynamics, with children experiencing increased disease burden and out-of-season epidemics as restrictions relaxed. Here we used serology from a newly developed quantitative multiplex assay to assess the post-pandemic immunity debt. We assessed age-specific antibody dynamics across a broad range of respiratory viruses, including influenza, respiratory syncytial virus, seasonal coronaviruses, and SARS-CoV-2 using serology collected in King County, Washington, US, from 2020-2022 (n = 1508). We found that respiratory virus immunodynamics differed between individuals <5 years of age and older individuals, with young children experiencing larger boosts and quicker waning of antibodies a"],"journal":["Nature communications"],"pubmed_title":["Multiplex serology reveals age-specific immunodynamics of respiratory pathogens in the wake of the COVID-19 pandemic."],"pmcid":["PMC12695953"],"funding_grant_id":["75N93021C00015","225001/Z/22/Z"],"pubmed_authors":["Hansen C","Blazevic R","Han P","Bents SJ","Waghmare A","Andrews C","Kimball L","Englund JA","Boeckh M","Stevens-Ayers T","Starita L","Adler A","Wolter N","Prentice R","Moyes J","Martin ET","Krantz EM","Viboud C","Perofsky AC","von Gottberg A","Cohen C","Hay JA","Maake L"],"additional_accession":[]},"is_claimable":false,"name":"Multiplex serology reveals age-specific immunodynamics of respiratory pathogens in the wake of the COVID-19 pandemic.","description":"The rebound of endemic respiratory viruses following the COVID-19 pandemic was marked by atypical transmission dynamics, with children experiencing increased disease burden and out-of-season epidemics as restrictions relaxed. Here we used serology from a newly developed quantitative multiplex assay to assess the post-pandemic immunity debt. We assessed age-specific antibody dynamics across a broad range of respiratory viruses, including influenza, respiratory syncytial virus, seasonal coronaviruses, and SARS-CoV-2 using serology collected in King County, Washington, US, from 2020-2022 (n = 1508). We found that respiratory virus immunodynamics differed between individuals <5 years of age and older individuals, with young children experiencing larger boosts and quicker waning of antibodies a","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-07T05:03:10.135Z","creation":"2026-06-07T03:06:27.023Z"},"accession":"S-EPMC12695953","cross_references":{"pubmed":["41372127"],"doi":["10.1038/s41467-025-65957-9"]}}