{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Austin G"],"funding":["NIDDK NIH HHS","Medical Research Council","Diabetes UK","Wellcome Trust","Biotechnology and Biological Sciences Research Council"],"pagination":["11010"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12696101"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Glucagon-like peptide-1 receptor (GLP-1R) agonists (GLP-1RAs) ameliorate mitochondrial health by increasing mitochondrial turnover in metabolically relevant tissues. Mitochondrial adaptation to metabolic stress is crucial to maintain pancreatic β-cell function and prevent type 2 diabetes (T2D) progression. While the GLP-1R is well-known to stimulate cAMP production leading to Protein Kinase A (PKA) and Exchange Protein Activated by cyclic AMP 2 (Epac2) activation, there is a lack of understanding of the molecular mechanisms linking GLP-1R signalling with mitochondrial and β-cell functional adaptation. Here, we present a comprehensive study in β-cell lines and primary islets that demonstrates that, following GLP-1RA stimulation, GLP-1R-positive endosomes associate with the endoplasmic retic"],"journal":["Nature communications"],"pubmed_title":["GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function."],"pmcid":["PMC12696101"],"funding_grant_id":["227745/Z/23/Z","104931/Z/14/Z","MR/X021467/1","301619/Z/23/Z","BB/L015129/1","UC4 DK098085","19/0006094"],"pubmed_authors":["Balkhiyarova Z","Bouzakri K","Gaboriau DCA","Manchanda Y","Tomas A","Oqua AI","Coyle H","Withers DJ","Jones B","Millership SJ","Zhu M","Majorovits E","Burgold S","Garlick E","Prokopenko I","Muller A","Austin G","El Eid L","Peres P","Solimena M","Montoya A","Poliakova Y","do R B F Lima MA","Nixon-Abell J"],"additional_accession":[]},"is_claimable":false,"name":"GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function.","description":"Glucagon-like peptide-1 receptor (GLP-1R) agonists (GLP-1RAs) ameliorate mitochondrial health by increasing mitochondrial turnover in metabolically relevant tissues. Mitochondrial adaptation to metabolic stress is crucial to maintain pancreatic β-cell function and prevent type 2 diabetes (T2D) progression. While the GLP-1R is well-known to stimulate cAMP production leading to Protein Kinase A (PKA) and Exchange Protein Activated by cyclic AMP 2 (Epac2) activation, there is a lack of understanding of the molecular mechanisms linking GLP-1R signalling with mitochondrial and β-cell functional adaptation. Here, we present a comprehensive study in β-cell lines and primary islets that demonstrates that, following GLP-1RA stimulation, GLP-1R-positive endosomes associate with the endoplasmic retic","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-06T03:55:21.679Z","creation":"2026-05-25T03:12:00.445Z"},"accession":"S-EPMC12696101","cross_references":{"pubmed":["41372122"],"doi":["10.1038/s41467-025-66115-x"]}}