{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lin W"],"funding":["Office of Isotope R and D and Production"],"pagination":["78"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12696209"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(1)"],"pubmed_abstract":["<h4>Background</h4>Promising developments in Pb-212 radiopharmaceutical therapies have increased demand for Pb-203 diagnostic agents. Building on previous work from various isotope production facilities, this study optimized Pb-203 production from electrodeposited Tl targets at Brookhaven National Laboratory (BNL). The additional supply of Pb-203 may help meet growing preclinical and clinical demands.<h4>Results</h4>Two Tl targets were irradiated at the Brookhaven Linac Isotope Producer facility with 30 ± 1 MeV protons, measured using previously published cross section data. Distribution coefficients for Pb Resin in acetate media were investigated for both Na<sup>+</sup> and K<sup>+</sup> cations, where potassium acetate was ~ 4 times more effective at stripping Pb from the Pb Resin. The T"],"journal":["EJNMMI radiopharmacy and chemistry"],"pubmed_title":["Establishing Pb-203 production from electrodeposited Tl targets at Brookhaven National Laboratory."],"pmcid":["PMC12696209"],"funding_grant_id":["Office of Isotope R and D and Production"],"pubmed_authors":["Medvedev DG","Lin W","Hatcher-Lamarre J","Cutler CS"],"additional_accession":[]},"is_claimable":false,"name":"Establishing Pb-203 production from electrodeposited Tl targets at Brookhaven National Laboratory.","description":"<h4>Background</h4>Promising developments in Pb-212 radiopharmaceutical therapies have increased demand for Pb-203 diagnostic agents. Building on previous work from various isotope production facilities, this study optimized Pb-203 production from electrodeposited Tl targets at Brookhaven National Laboratory (BNL). The additional supply of Pb-203 may help meet growing preclinical and clinical demands.<h4>Results</h4>Two Tl targets were irradiated at the Brookhaven Linac Isotope Producer facility with 30 ± 1 MeV protons, measured using previously published cross section data. Distribution coefficients for Pb Resin in acetate media were investigated for both Na<sup>+</sup> and K<sup>+</sup> cations, where potassium acetate was ~ 4 times more effective at stripping Pb from the Pb Resin. The T","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-06T00:27:42.688Z","creation":"2026-05-24T03:11:18.494Z"},"accession":"S-EPMC12696209","cross_references":{"pubmed":["41369850"],"doi":["10.1186/s41181-025-00403-1"]}}