biostudies-literatureLin WOffice of Isotope R and D and Production78https://www.ebi.ac.uk/biostudies/studies/S-EPMC12696209biostudies-literatureUnknown10(1)<h4>Background</h4>Promising developments in Pb-212 radiopharmaceutical therapies have increased demand for Pb-203 diagnostic agents. Building on previous work from various isotope production facilities, this study optimized Pb-203 production from electrodeposited Tl targets at Brookhaven National Laboratory (BNL). The additional supply of Pb-203 may help meet growing preclinical and clinical demands.<h4>Results</h4>Two Tl targets were irradiated at the Brookhaven Linac Isotope Producer facility with 30 ± 1 MeV protons, measured using previously published cross section data. Distribution coefficients for Pb Resin in acetate media were investigated for both Na⁺ and K⁺ cations, where potassium acetate was ~ 4 times more effective at stripping Pb from the Pb Resin. The TEJNMMI radiopharmacy and chemistryEstablishing Pb-203 production from electrodeposited Tl targets at Brookhaven National Laboratory.PMC12696209Office of Isotope R and D and ProductionMedvedev DGLin WHatcher-Lamarre JCutler CSfalseEstablishing Pb-203 production from electrodeposited Tl targets at Brookhaven National Laboratory.<h4>Background</h4>Promising developments in Pb-212 radiopharmaceutical therapies have increased demand for Pb-203 diagnostic agents. Building on previous work from various isotope production facilities, this study optimized Pb-203 production from electrodeposited Tl targets at Brookhaven National Laboratory (BNL). The additional supply of Pb-203 may help meet growing preclinical and clinical demands.<h4>Results</h4>Two Tl targets were irradiated at the Brookhaven Linac Isotope Producer facility with 30 ± 1 MeV protons, measured using previously published cross section data. Distribution coefficients for Pb Resin in acetate media were investigated for both Na⁺ and K⁺ cations, where potassium acetate was ~ 4 times more effective at stripping Pb from the Pb Resin. The T2025-01-01T00:00:00Z2025 Dec2026-06-06T00:27:42.688Z2026-05-24T03:11:18.494ZS-EPMC126962094136985010.1186/s41181-025-00403-1