{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Dial-Mag Investigator Writing Committee*"],"pubmed_abstract":["<h4>Background</h4>In individuals receiving hemodialysis, lower serum magnesium concentrations are associated with a higher risk of death and cardiovascular disease and more discomfort from muscle cramps. Small trials suggest that increasing serum magnesium by using a higher concentration of dialysate magnesium may be beneficial. This protocol outlines a large, randomized trial examining the effects of adopting a high versus low concentration of dialysate magnesium as a hemodialysis center-wide policy on the risk of mortality, major adverse cardiovascular events, and the burden of muscle cramps.<h4>Objective</h4>To determine whether implementing a dialysate magnesium concentration of 0.75 mmol/L versus ≤ 0.5 mmol/L as a hemodialysis center-wide policy, for up to 4 years, affects (1) the ra"],"journal":["Canadian journal of kidney health and disease"],"pagination":["20543581251385011"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12696322"],"repository":["biostudies-literature"],"pubmed_title":["Outcomes of Adopting a Higher Versus Lower Concentration of Hemodialysate Magnesium as a Center-Wide Policy (Dial-Mag): A Clinical Research Protocol of a Pragmatic, Registry-Based, Cluster Randomized Trial."],"pmcid":["PMC12696322"],"pubmed_authors":["Shah N","Tonelli M","Brown PA","Dev V","Kumar Kolusu E","Lacson E","Dhruve M","Gregor L","Perkins D","Sontrop JM","Vorster H","Dial-Mag Investigator Writing Committee*","Kammila S","Chan CT","Shulman T","Tangri N","Garg AX","Molnar AO","Yao S","Berry D","Hiremath S","Zacharias J","Parmar MS","Walters J","Cowan AC","Whitlock RH","Bohm C","Nathoo B","Louis IS","Beaubien E","Antonsen J","Anderson S","Wadehra DB","Day NE","Mazurat A","Al-Jaishi AA","Steele A","Djurdjev O","Kiaii M","Killin L","Cuerden MS","Bagga A","Blake PG","Silver SA","Singh A","Quinn K","Wald R","Oliver MJ","Romann A","Luo B","Thompson S","Nistico A","Acedillo RR","Bueti J","Harris C","Pandeya S","Sasal J","Cote B","Joseph G","Ting RH","MacRae JM"],"additional_accession":[]},"is_claimable":false,"name":"Outcomes of Adopting a Higher Versus Lower Concentration of Hemodialysate Magnesium as a Center-Wide Policy (Dial-Mag): A Clinical Research Protocol of a Pragmatic, Registry-Based, Cluster Randomized Trial.","description":"<h4>Background</h4>In individuals receiving hemodialysis, lower serum magnesium concentrations are associated with a higher risk of death and cardiovascular disease and more discomfort from muscle cramps. Small trials suggest that increasing serum magnesium by using a higher concentration of dialysate magnesium may be beneficial. This protocol outlines a large, randomized trial examining the effects of adopting a high versus low concentration of dialysate magnesium as a hemodialysis center-wide policy on the risk of mortality, major adverse cardiovascular events, and the burden of muscle cramps.<h4>Objective</h4>To determine whether implementing a dialysate magnesium concentration of 0.75 mmol/L versus ≤ 0.5 mmol/L as a hemodialysis center-wide policy, for up to 4 years, affects (1) the ra","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-06T03:46:52.962Z","creation":"2026-05-25T03:11:28.509Z"},"accession":"S-EPMC12696322","cross_references":{"pubmed":["41393273"],"doi":["10.1177/20543581251385011"]}}