{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["41(6)"],"submitter":["Li Q"],"funding":["Sanofi"],"pubmed_abstract":["Recombinant adeno-associated viruses (AAVs) with precise genome editing and cell-virus interaction have become a promising delivery tool for gene therapy. A robust AAV purification process is crucial for ensuring therapeutic efficacy. The challenges of AAV purification process development encompass limited material availability during early-stage development, high cost-of-goods compared to traditional biologics, and short development timelines for the critical first-in-human stages. The key to overcoming these challenges is to leverage high throughput (HTP) methods. In this article, an integrated end-to-end HTP workflow is proposed, utilizing a resin tip as the purification module and incorporating an HTP analytical toolkit on one platform. Purification parameters, including binding capaci"],"journal":["Biotechnology progress"],"pagination":["e70053"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12696448"],"repository":["biostudies-literature"],"pubmed_title":["Accelerating AAV purification process development using high-throughput resin tip module."],"pmcid":["PMC12696448"],"pubmed_authors":["Benner S","Li Q","Ma J","Hadidi M"],"additional_accession":[]},"is_claimable":false,"name":"Accelerating AAV purification process development using high-throughput resin tip module.","description":"Recombinant adeno-associated viruses (AAVs) with precise genome editing and cell-virus interaction have become a promising delivery tool for gene therapy. A robust AAV purification process is crucial for ensuring therapeutic efficacy. The challenges of AAV purification process development encompass limited material availability during early-stage development, high cost-of-goods compared to traditional biologics, and short development timelines for the critical first-in-human stages. The key to overcoming these challenges is to leverage high throughput (HTP) methods. In this article, an integrated end-to-end HTP workflow is proposed, utilizing a resin tip as the purification module and incorporating an HTP analytical toolkit on one platform. Purification parameters, including binding capaci","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov-Dec","modification":"2026-06-06T00:35:24.149Z","creation":"2026-05-24T03:12:03.06Z"},"accession":"S-EPMC12696448","cross_references":{"pubmed":["40678841"],"doi":["10.1002/btpr.70053"]}}