biostudies-literatureUnknownCai X<h4>Abstract</h4>The effectiveness of GnRH antagonist protocol remains controversial due to inconsistent conclusions and inadequate subgroup analyses. The aim of this study was to provide some references for clinicians when choosing GnRH antagonist protocol for patients. A retrospective cohort study analyzed 1845 infertility patients aged 20-50 years who underwent IVF/ICSI treatment. They used the GnRH agonist or GnRH antagonist protocol at the Assisted Reproduction Center of Wuhan Union Hospital from June 2023 to June 2024. One-to-one PSM was used to match the population characteristics. The difference of cumulative live birthrates (CLBR) was analyzed by multivariate logistic regression. Endometrial tissues were obtained and the endometrial receptivity was determined by detecting the exprReproduction & fertilityRAF-25-0045https://www.ebi.ac.uk/biostudies/studies/S-EPMC12697241biostudies-literatureGnRH agonist improves CLBR after one IVF cycle: a propensity score-matched and molecular mechanism study.PMC12697241Liu YDing HCai XXiong WfalseGnRH agonist improves CLBR after one IVF cycle: a propensity score-matched and molecular mechanism study.<h4>Abstract</h4>The effectiveness of GnRH antagonist protocol remains controversial due to inconsistent conclusions and inadequate subgroup analyses. The aim of this study was to provide some references for clinicians when choosing GnRH antagonist protocol for patients. A retrospective cohort study analyzed 1845 infertility patients aged 20-50 years who underwent IVF/ICSI treatment. They used the GnRH agonist or GnRH antagonist protocol at the Assisted Reproduction Center of Wuhan Union Hospital from June 2023 to June 2024. One-to-one PSM was used to match the population characteristics. The difference of cumulative live birthrates (CLBR) was analyzed by multivariate logistic regression. Endometrial tissues were obtained and the endometrial receptivity was determined by detecting the expr2025-01-01T00:00:00Z2025 Nov2026-06-06T01:27:26.259Z2026-05-24T03:11:32.686ZS-EPMC126972414128376410.1530/RAF-25-0045