{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lee Y"],"funding":["Howard Hughes Medical Institute","National Institutes of Health","National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["116329"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12697309"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["44(10)"],"pubmed_abstract":["Nuclear RNA homeostasis depends on the balance of transcription, RNA processing, degradation, and transport between the nucleus and cytoplasm. RNA degradation directed by the Integrator, nuclear exosome targeting (NEXT), and nuclear exosome complexes controls the accumulation of aberrant nuclear RNA. Here, we report that Drosophila oogenesis requires the Integrator, NEXT, and nuclear exosome complexes. Depletion of Integrator, NEXT, or nuclear exosome components in Drosophila female germ cells causes infertility and accumulation of 3' extended small nuclear RNAs, promoter upstream transcripts, and cryptic transcripts. Our data highlight the essential role of nuclear RNA degradation and processing in Drosophila oogenesis and provide a catalog of RNAs whose nuclear levels are regulated by th"],"journal":["Cell reports"],"pubmed_title":["Defining the roles of the Integrator, NEXT, and nuclear exosome complexes in Drosophila oogenesis."],"pmcid":["PMC12697309"],"funding_grant_id":["R35 GM136275"],"pubmed_authors":["Tipping C","Biasini A","Lee Y","Hong SH","Zamore PD"],"additional_accession":[]},"is_claimable":false,"name":"Defining the roles of the Integrator, NEXT, and nuclear exosome complexes in Drosophila oogenesis.","description":"Nuclear RNA homeostasis depends on the balance of transcription, RNA processing, degradation, and transport between the nucleus and cytoplasm. RNA degradation directed by the Integrator, nuclear exosome targeting (NEXT), and nuclear exosome complexes controls the accumulation of aberrant nuclear RNA. Here, we report that Drosophila oogenesis requires the Integrator, NEXT, and nuclear exosome complexes. Depletion of Integrator, NEXT, or nuclear exosome components in Drosophila female germ cells causes infertility and accumulation of 3' extended small nuclear RNAs, promoter upstream transcripts, and cryptic transcripts. Our data highlight the essential role of nuclear RNA degradation and processing in Drosophila oogenesis and provide a catalog of RNAs whose nuclear levels are regulated by th","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-06T02:17:23.409Z","creation":"2026-05-24T03:12:25.921Z"},"accession":"S-EPMC12697309","cross_references":{"pubmed":["40991927"],"doi":["10.1016/j.celrep.2025.116329"]}}