{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["26(3)"],"submitter":["Malerba C"],"pubmed_abstract":["McConnell's sign, characterized by hypokinesia of the mid-free wall of the right ventricle (RV) with preserved apical contractility, is a well-recognized echocardiographic marker in acute pulmonary embolism (PE). However, its reverse variant-apical akinesia with preserved basal function-is rare and less understood. We report the case of an 85-year-old woman presenting with acute PE, who exhibited a rare form of RV dysfunction known as Reverse McConnell's sign. Multimodality imaging-including computed tomography (CT), transthoracic echocardiography, and cardiac magnetic resonance (CMR)-revealed apical RV akinesia and a concurrent intracavitary thrombus at the RV apex. Based on imaging, laboratory biomarkers, and clinical findings, an intermediate-high risk PE was diagnosed. The patient was "],"journal":["Heart views : the official journal of the Gulf Heart Association"],"pagination":["198-203"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12697744"],"repository":["biostudies-literature"],"pubmed_title":["Multimodality Imaging Evaluation of Reverse McConnell's Sign and Right Ventricular Apical Thrombosis in Acute Pulmonary Embolism."],"pmcid":["PMC12697744"],"pubmed_authors":["Malerba C","Camastra G","Ciolina F","Badagliacca R","Sbarbati S","Cacciotti L","Arcari L"],"additional_accession":[]},"is_claimable":false,"name":"Multimodality Imaging Evaluation of Reverse McConnell's Sign and Right Ventricular Apical Thrombosis in Acute Pulmonary Embolism.","description":"McConnell's sign, characterized by hypokinesia of the mid-free wall of the right ventricle (RV) with preserved apical contractility, is a well-recognized echocardiographic marker in acute pulmonary embolism (PE). However, its reverse variant-apical akinesia with preserved basal function-is rare and less understood. We report the case of an 85-year-old woman presenting with acute PE, who exhibited a rare form of RV dysfunction known as Reverse McConnell's sign. Multimodality imaging-including computed tomography (CT), transthoracic echocardiography, and cardiac magnetic resonance (CMR)-revealed apical RV akinesia and a concurrent intracavitary thrombus at the RV apex. Based on imaging, laboratory biomarkers, and clinical findings, an intermediate-high risk PE was diagnosed. The patient was ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul-Sep","modification":"2026-05-26T11:06:49.598Z","creation":"2026-05-24T03:12:17.983Z"},"accession":"S-EPMC12697744","cross_references":{"pubmed":["41393819"],"doi":["10.4103/heartviews.heartviews_113_25"]}}