biostudies-literatureManoharan SSwiss National Science FoundationStrategic Focus Area on Advanced Manufacturing (SFA-AM) of the ETH Domaine12411https://www.ebi.ac.uk/biostudies/studies/S-EPMC12697772biostudies-literatureUnknown12(46)A foundational demonstration of a tetherless, ingestible bioprinter capable of controlled bioink deposition and patterning for potential applications in endoluminal tissue repair is presented. This ingestible microdevice, the first-of-its-kind, operates without tethers or onboard electronics and is guided using external imaging and magnetic actuation. By integrating near-infrared triggering and magnetic guidance, both applied from outside the body, the ability to guide the pill over target sites and deposit bioink in defined patterns, for ulcer coverage or hemorrhage sealing in ex vivo models is demonstrated. To enable this, the interplay is modeled and optimized between magnetic forces and stick-slip dynamics at the tissue interface, facilitating predictable surface-mediated navigation anAdvanced science (Weinheim, Baden-Wurttemberg, Germany)A Pill That Prints-An Ingestible Bioprinter for Non-Invasive Structured Bioink Deposition.PMC1269777200021_185086185086Subramanian VManoharan SfalseA Pill That Prints-An Ingestible Bioprinter for Non-Invasive Structured Bioink Deposition.A foundational demonstration of a tetherless, ingestible bioprinter capable of controlled bioink deposition and patterning for potential applications in endoluminal tissue repair is presented. This ingestible microdevice, the first-of-its-kind, operates without tethers or onboard electronics and is guided using external imaging and magnetic actuation. By integrating near-infrared triggering and magnetic guidance, both applied from outside the body, the ability to guide the pill over target sites and deposit bioink in defined patterns, for ulcer coverage or hemorrhage sealing in ex vivo models is demonstrated. To enable this, the interplay is modeled and optimized between magnetic forces and stick-slip dynamics at the tissue interface, facilitating predictable surface-mediated navigation an2025-01-01T00:00:00Z2025 Dec2026-06-06T01:27:02.413Z2026-05-24T03:11:30.416ZS-EPMC126977724099993210.1002/advs.202512411