{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang H"],"funding":["Fundamental Research Funds for the Central Universities","National Natural Science Foundation of China","Third People's Hospital of Chengdu Scientific Research Project","Chengdu Science and Technology Bureau project"],"pagination":["e09998"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12697898"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(46)"],"pubmed_abstract":["A multifunctional high internal phase Pickering emulsion (HIPPE-QU) is developed to address immune dysregulation in periodontitis by reprogramming macrophage metabolism and promoting tissue regeneration. Fabricated via one-step homogenization, HIPPE-QU features a 75% internal phase and is co-stabilized by gelatin nanoparticles (GNPs) and copper-doped hydroxyapatite (HA-Cu), forming a gel-like, injectable emulgel suitable for clinical application. Hydrophobic quercetin (QU) is encapsulated in the internal phase and chelates with Cu<sup>2</sup>⁺ and Ca<sup>2</sup>⁺ at the interface, enabling sustained and pH-responsive release under the acidic periodontal environment. The spatially organized loading strategy across dispersed, interfacial, and internal phases yields synergistic antibacterial "],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Interfacial Coordination-Engineered Emulgel Modulates the Osteo-Immune Microenvironment in Periodontitis Treatment Via HIF1 Signaling Pathway-Induced Metabolic Reprogramming."],"pmcid":["PMC12697898"],"funding_grant_id":["CSY-YN-01-2023-014","2024-YF05-00183-SN","2023PI13","2024-YF05-00178-SN","82101012","22172120","2682025ZTPY044"],"pubmed_authors":["Peng X","Li J","Tan H","Zhang H","Yuan Q","Lin W","Weng J","Guo T","Li L","Yang X","Wang M","Huang X","Chen X","Chen R"],"additional_accession":[]},"is_claimable":false,"name":"Interfacial Coordination-Engineered Emulgel Modulates the Osteo-Immune Microenvironment in Periodontitis Treatment Via HIF1 Signaling Pathway-Induced Metabolic Reprogramming.","description":"A multifunctional high internal phase Pickering emulsion (HIPPE-QU) is developed to address immune dysregulation in periodontitis by reprogramming macrophage metabolism and promoting tissue regeneration. Fabricated via one-step homogenization, HIPPE-QU features a 75% internal phase and is co-stabilized by gelatin nanoparticles (GNPs) and copper-doped hydroxyapatite (HA-Cu), forming a gel-like, injectable emulgel suitable for clinical application. Hydrophobic quercetin (QU) is encapsulated in the internal phase and chelates with Cu<sup>2</sup>⁺ and Ca<sup>2</sup>⁺ at the interface, enabling sustained and pH-responsive release under the acidic periodontal environment. The spatially organized loading strategy across dispersed, interfacial, and internal phases yields synergistic antibacterial ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-07-15T11:20:47.68Z","creation":"2026-07-04T03:11:27.764Z"},"accession":"S-EPMC12697898","cross_references":{"pubmed":["41020683"],"doi":["10.1002/advs.202509998"]}}