biostudies-literatureZhang HFundamental Research Funds for the Central UniversitiesNational Natural Science Foundation of ChinaThird People's Hospital of Chengdu Scientific Research ProjectChengdu Science and Technology Bureau projecte09998https://www.ebi.ac.uk/biostudies/studies/S-EPMC12697898biostudies-literatureUnknown12(46)A multifunctional high internal phase Pickering emulsion (HIPPE-QU) is developed to address immune dysregulation in periodontitis by reprogramming macrophage metabolism and promoting tissue regeneration. Fabricated via one-step homogenization, HIPPE-QU features a 75% internal phase and is co-stabilized by gelatin nanoparticles (GNPs) and copper-doped hydroxyapatite (HA-Cu), forming a gel-like, injectable emulgel suitable for clinical application. Hydrophobic quercetin (QU) is encapsulated in the internal phase and chelates with Cu²⁺ and Ca²⁺ at the interface, enabling sustained and pH-responsive release under the acidic periodontal environment. The spatially organized loading strategy across dispersed, interfacial, and internal phases yields synergistic antibacterial Advanced science (Weinheim, Baden-Wurttemberg, Germany)Interfacial Coordination-Engineered Emulgel Modulates the Osteo-Immune Microenvironment in Periodontitis Treatment Via HIF1 Signaling Pathway-Induced Metabolic Reprogramming.PMC12697898CSY-YN-01-2023-0142024-YF05-00183-SN2023PI132024-YF05-00178-SN82101012221721202682025ZTPY044Peng XLi JTan HZhang HYuan QLin WWeng JGuo TLi LYang XWang MHuang XChen XChen RfalseInterfacial Coordination-Engineered Emulgel Modulates the Osteo-Immune Microenvironment in Periodontitis Treatment Via HIF1 Signaling Pathway-Induced Metabolic Reprogramming.A multifunctional high internal phase Pickering emulsion (HIPPE-QU) is developed to address immune dysregulation in periodontitis by reprogramming macrophage metabolism and promoting tissue regeneration. Fabricated via one-step homogenization, HIPPE-QU features a 75% internal phase and is co-stabilized by gelatin nanoparticles (GNPs) and copper-doped hydroxyapatite (HA-Cu), forming a gel-like, injectable emulgel suitable for clinical application. Hydrophobic quercetin (QU) is encapsulated in the internal phase and chelates with Cu²⁺ and Ca²⁺ at the interface, enabling sustained and pH-responsive release under the acidic periodontal environment. The spatially organized loading strategy across dispersed, interfacial, and internal phases yields synergistic antibacterial 2025-01-01T00:00:00Z2025 Dec2026-07-15T11:20:47.68Z2026-07-04T03:11:27.764ZS-EPMC126978984102068310.1002/advs.202509998