biostudies-literatureUnknown26(6)London KS<h4>Introduction</h4>Take-home naloxone (THN) programs in emergency departments (ED) can reduce opioid overdose deaths by providing naloxone directly to at-risk patients before discharge. However, sustainable models that integrate reimbursement and workflow alignment remain limited.<h4>Methods</h4>A reimbursable ED-led THN program was developed across a large regional health system. The program used electronic health record (EHR)-integrated ordering, on-site kit dispensing, and third-party insurance billing when available. Kits were stocked in automated medication dispensing systems and supplemented by city-provided stock for uninsured patients. Pilot outcomes included kits dispensed and reimbursement rates across eight participating EDs.<h4>Results</h4>A total of 2,520 naloxone kits were The western journal of emergency medicine1605-1610https://www.ebi.ac.uk/biostudies/studies/S-EPMC12698159biostudies-literatureDevelopment of a Low-Barrier, Reimbursable Take-Home Naloxone Program at a Regional Health System.PMC12698159Lockstein DReed MLondon KSRandolph FGoodstein DPatel SPacitti RWarrick-Stone TRashid JAlexander KCherney AfalseDevelopment of a Low-Barrier, Reimbursable Take-Home Naloxone Program at a Regional Health System.<h4>Introduction</h4>Take-home naloxone (THN) programs in emergency departments (ED) can reduce opioid overdose deaths by providing naloxone directly to at-risk patients before discharge. However, sustainable models that integrate reimbursement and workflow alignment remain limited.<h4>Methods</h4>A reimbursable ED-led THN program was developed across a large regional health system. The program used electronic health record (EHR)-integrated ordering, on-site kit dispensing, and third-party insurance billing when available. Kits were stocked in automated medication dispensing systems and supplemented by city-provided stock for uninsured patients. Pilot outcomes included kits dispensed and reimbursement rates across eight participating EDs.<h4>Results</h4>A total of 2,520 naloxone kits were 2025-01-01T00:00:00Z2025 Nov2026-06-06T01:24:41.306Z2026-05-24T03:11:51.27ZS-EPMC126981594138006610.5811/westjem.47387