{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Li Y"],"pubmed_abstract":["<h4>Aims</h4>To explore the plasma exosomal miRNA expression profiles in patients with abdominal obesity and type 2 diabetes mellitus (T2DM), identify differentially expressed exosomal m4RNAs, and evaluate the potential of selected exosomal miRNAs as biomarkers for abdominal obesity-related T2DM.<h4>Methods</h4>In the screening phase, high-throughput sequencing was used to detect the plasma exosomal miRNA expression profiles of non-abdominal obese individuals with normal glucose metabolism (NAO/NG, N = 4), abdominal obese individuals with normal glucose metabolism (AO/NG, N = 4), and abdominal obese T2DM patients (AO/T2DM, N = 4). Five differentially expressed miRNAs were identified. In the independent validation phase, RT-qPCR was performed to validate the expression of these miRNAs in th"],"journal":["Frontiers in endocrinology"],"pagination":["1656132"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12698432"],"repository":["biostudies-literature"],"pubmed_title":["Plasma-derived exosomal miRNAs as potentially novel biomarkers for type 2 diabetes mellitus with abdominal obesity."],"pmcid":["PMC12698432"],"pubmed_authors":["Li Y","Feng L","Li Z","Xing L","Zheng L","Wang Y","Feng R","Jia J"],"additional_accession":[]},"is_claimable":false,"name":"Plasma-derived exosomal miRNAs as potentially novel biomarkers for type 2 diabetes mellitus with abdominal obesity.","description":"<h4>Aims</h4>To explore the plasma exosomal miRNA expression profiles in patients with abdominal obesity and type 2 diabetes mellitus (T2DM), identify differentially expressed exosomal m4RNAs, and evaluate the potential of selected exosomal miRNAs as biomarkers for abdominal obesity-related T2DM.<h4>Methods</h4>In the screening phase, high-throughput sequencing was used to detect the plasma exosomal miRNA expression profiles of non-abdominal obese individuals with normal glucose metabolism (NAO/NG, N = 4), abdominal obese individuals with normal glucose metabolism (AO/NG, N = 4), and abdominal obese T2DM patients (AO/T2DM, N = 4). Five differentially expressed miRNAs were identified. In the independent validation phase, RT-qPCR was performed to validate the expression of these miRNAs in th","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-06T02:52:17.557Z","creation":"2026-05-24T03:13:07.574Z"},"accession":"S-EPMC12698432","cross_references":{"pubmed":["41393285"],"doi":["10.3389/fendo.2025.1656132"]}}