{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Ke Q"],"pubmed_abstract":["Ovarian cancer has the worst prognosis among major gynecological cancers. Current therapies include platinum, Taxol, angiogenesis inhibitors, and poly[ADP-ribose]polymerase (PARP) inhibitors. However, resistance develops in most ovarian cancer patients. Identification of more pro-tumor factors in ovarian cancer may provide insights into ovarian cancer biology and therapy. In this study, we find ZKSCAN3, a zinc-finger transcription factor, is overexpressed in ovarian cancer. We show that ZKSCAN3 promotes ovarian cancer cell proliferation. Through RNA-Seq and chromatin immunoprecipitation (ChIP)-seq, HSPB1 is identified as a target gene of ZKSCAN3. HSPB1 expression is significantly decreased upon suppressing ZKSCAN3 expression. Suppressing HSPB1 expression also inhibits ovarian cancer cell p"],"journal":["Frontiers in molecular biosciences"],"pagination":["1623062"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12698437"],"repository":["biostudies-literature"],"pubmed_title":["ZKSCAN3 promotes ovarian cancer cell proliferation by increasing HSPB1 expression."],"pmcid":["PMC12698437"],"pubmed_authors":["Sun L","Li Z","Fan L","Ke Q","Song T","Li N","Zhao H"],"additional_accession":[]},"is_claimable":false,"name":"ZKSCAN3 promotes ovarian cancer cell proliferation by increasing HSPB1 expression.","description":"Ovarian cancer has the worst prognosis among major gynecological cancers. Current therapies include platinum, Taxol, angiogenesis inhibitors, and poly[ADP-ribose]polymerase (PARP) inhibitors. However, resistance develops in most ovarian cancer patients. Identification of more pro-tumor factors in ovarian cancer may provide insights into ovarian cancer biology and therapy. In this study, we find ZKSCAN3, a zinc-finger transcription factor, is overexpressed in ovarian cancer. We show that ZKSCAN3 promotes ovarian cancer cell proliferation. Through RNA-Seq and chromatin immunoprecipitation (ChIP)-seq, HSPB1 is identified as a target gene of ZKSCAN3. HSPB1 expression is significantly decreased upon suppressing ZKSCAN3 expression. Suppressing HSPB1 expression also inhibits ovarian cancer cell p","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-06T02:57:41.675Z","creation":"2026-05-25T03:07:33.889Z"},"accession":"S-EPMC12698437","cross_references":{"pubmed":["41393507"],"doi":["10.3389/fmolb.2025.1623062"]}}