biostudies-literatureUnknown13Gao Y<h4>Introduction</h4>As emerging instruments in digital health, large language models (LLMs) assimilate values and attitudes from human-generated data, thereby possessing the latent capacity to reflect public health perspectives. This study investigates into the representational biases of LLMs through the lens of health equity. We propose and empirically validate a three-dimensional explanatory framework encompassing Data Resources, Opinion Distribution, and Prompt Language, positing that prompts are not just communicative media but critical conduits that embed cultural context.<h4>Methods</h4>Utilizing a selection of prominent LLMs from the United States and China-namely Gemini 2.5 Pro, GPT-5, DeepSeek-V3, and Qwen 3. We conduct a systematic empirical analysis of their performance in reprFrontiers in public health1705082https://www.ebi.ac.uk/biostudies/studies/S-EPMC12698530biostudies-literatureImplicit bias in digital health: systematic biases in large language models' representation of global public health attitudes and challenges to health equity.PMC12698530Jahng SGFeng YGao YfalseImplicit bias in digital health: systematic biases in large language models' representation of global public health attitudes and challenges to health equity.<h4>Introduction</h4>As emerging instruments in digital health, large language models (LLMs) assimilate values and attitudes from human-generated data, thereby possessing the latent capacity to reflect public health perspectives. This study investigates into the representational biases of LLMs through the lens of health equity. We propose and empirically validate a three-dimensional explanatory framework encompassing Data Resources, Opinion Distribution, and Prompt Language, positing that prompts are not just communicative media but critical conduits that embed cultural context.<h4>Methods</h4>Utilizing a selection of prominent LLMs from the United States and China-namely Gemini 2.5 Pro, GPT-5, DeepSeek-V3, and Qwen 3. We conduct a systematic empirical analysis of their performance in repr2025-01-01T00:00:00Z20252026-06-06T02:54:07.793Z2026-05-24T03:12:55.952ZS-EPMC126985304139301810.3389/fpubh.2025.1705082