{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Weng B"],"pubmed_abstract":["<h4>Background</h4>The associations between analgesia and/or sedation exposure and adverse outcomes in very preterm infants remain controversial. Evidence linking these medications to moderate-to-severe bronchopulmonary dysplasia (BPD) and long-term neurodevelopmental outcomes is particularly limited in large Chinese preterm cohorts.<h4>Objective</h4>The primary aim was to investigate the associations between exposure to analgesia/sedation and the composite outcome of BPD or death. The secondary aim was to assess the association with neurodevelopmental outcomes at 18 months.<h4>Methods</h4>This large, retrospective cohort study included preterm infants (gestational age < 32 weeks) admitted to a tertiary NICU in Shanghai, China, from 2018 to 2022. The primary outcomes were two composite mea"],"journal":["Frontiers in medicine"],"pagination":["1694251"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12698585"],"repository":["biostudies-literature"],"pubmed_title":["Analgesia and sedation increases bronchopulmonary dysplasia risk without significant neurodevelopmental impairment in very preterm infants."],"pmcid":["PMC12698585"],"pubmed_authors":["Weng B","Liu Y","Cai C","Zhang Y","Yan C"],"additional_accession":[]},"is_claimable":false,"name":"Analgesia and sedation increases bronchopulmonary dysplasia risk without significant neurodevelopmental impairment in very preterm infants.","description":"<h4>Background</h4>The associations between analgesia and/or sedation exposure and adverse outcomes in very preterm infants remain controversial. Evidence linking these medications to moderate-to-severe bronchopulmonary dysplasia (BPD) and long-term neurodevelopmental outcomes is particularly limited in large Chinese preterm cohorts.<h4>Objective</h4>The primary aim was to investigate the associations between exposure to analgesia/sedation and the composite outcome of BPD or death. The secondary aim was to assess the association with neurodevelopmental outcomes at 18 months.<h4>Methods</h4>This large, retrospective cohort study included preterm infants (gestational age < 32 weeks) admitted to a tertiary NICU in Shanghai, China, from 2018 to 2022. The primary outcomes were two composite mea","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-05-26T14:04:47.81Z","creation":"2026-05-24T03:13:03.176Z"},"accession":"S-EPMC12698585","cross_references":{"pubmed":["41393134"],"doi":["10.3389/fmed.2025.1694251"]}}