{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Berner J"],"funding":["Bundesministerium für Bildung und Forschung (Federal Ministry of Education and Research)","EC | European Regional Development Fund (Europski Fond za Regionalni Razvoj)","Bundesministerium für Bildung und Forschung","EC | European Regional Development Fund"],"pagination":["884"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12698709"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Infected skin tumors are challenging to treat and frequently result in tumor progression, relapses, and post-surgical complications. Moreover, bacterial infections significantly contribute to tumor therapy resistance as they release tumor microenvironment (TME)-modulating molecules. Immune or cancer cells can recognize these pathogen-associated molecular patterns (PAMPs), initiating signaling and pro- or antitumoral response. Hence, understanding PAMPs in tumor therapy may improve the understanding and efficacy of cancer treatment. Cold gas plasma treatment has shown promise in treating infected, ulcerative head and neck cancers. Here, we elucidated gas plasma-induced bacterial PAMP release and their combination with direct gas plasma exposure in skin cancer cells in vitro. Evaluating meta"],"journal":["Cell death & disease"],"pubmed_title":["Gas plasma-induced bacterial PAMP release promotes skin cancer cell death."],"pmcid":["PMC12698709"],"funding_grant_id":["03Z22DN11","03Z22Di1","EXF-25-1043"],"pubmed_authors":["Freund E","Bekeschus S","Sieben M","Berner J","Schulan P","Miebach L"],"additional_accession":[]},"is_claimable":false,"name":"Gas plasma-induced bacterial PAMP release promotes skin cancer cell death.","description":"Infected skin tumors are challenging to treat and frequently result in tumor progression, relapses, and post-surgical complications. Moreover, bacterial infections significantly contribute to tumor therapy resistance as they release tumor microenvironment (TME)-modulating molecules. Immune or cancer cells can recognize these pathogen-associated molecular patterns (PAMPs), initiating signaling and pro- or antitumoral response. Hence, understanding PAMPs in tumor therapy may improve the understanding and efficacy of cancer treatment. Cold gas plasma treatment has shown promise in treating infected, ulcerative head and neck cancers. Here, we elucidated gas plasma-induced bacterial PAMP release and their combination with direct gas plasma exposure in skin cancer cells in vitro. Evaluating meta","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-06T02:03:31.259Z","creation":"2026-05-24T03:12:19.021Z"},"accession":"S-EPMC12698709","cross_references":{"pubmed":["41345386"],"doi":["10.1038/s41419-025-08283-8"]}}