{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hwang J"],"funding":["Institute of Information and Communications Technology Planning and Evaluation (IITP) funded by the Korea government (MSIT)","Basic Science Research Program through the National Research Foundation of Korea funded by the Korea government (MSIT)","National Research Foundation of Korea grant funded by the Korea government (MSIT)","Korea Dementia Research Project through the Korea Dementia Research Center (KDRC) funded by the Korea government (Ministry of Health & Welfare and MSIT)","National Research Council of Science and Technology (NST) Aging Convergence Research Center funded by the Korea government (MSIT)"],"pagination":["262"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12699802"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["<h4>Background</h4>Multidomain lifestyle interventions have shown effectiveness in preventing dementia, but identifying high-risk groups most likely to benefit remains unclear.<h4>Methods</h4>We re-evaluated the SUPERBRAIN-MEET multidomain intervention study in mild cognitive impairment (MCI) patients, incorporating polygenic risk scores (PRS) for Alzheimer's disease and APOE ε4 status using Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) total index as the primary outcome.<h4>Results</h4>Both intervention and control groups showed cognitive improvement over 24 weeks, with greater gains in the intervention arm. Relative intervention efficacy (RIE) increased with higher genetic risk, being most pronounced among APOE ε4 carriers and individuals with high PRS. When "],"journal":["Alzheimer's research & therapy"],"pubmed_title":["Polygenicity and APOE ε4 shape response to intervention in mild cognitive impairment."],"pmcid":["PMC12699802"],"funding_grant_id":["No. 2023R1A2C2002925","No. NRF-2020M3E5D2A01084721","No. 2022-0-00448/RS-2022-II220448","No. RS-2021-KH112636 and No. RS-2024-00337993","No. CRC22013-600"],"pubmed_authors":["Na HR","Jeong JH","Sung J","Jung J","Lee SJ","Lee J","Lee H","Cho SH","Hong CH","Hwang J","Choi SH","Park YK","Moon SY"],"additional_accession":[]},"is_claimable":false,"name":"Polygenicity and APOE ε4 shape response to intervention in mild cognitive impairment.","description":"<h4>Background</h4>Multidomain lifestyle interventions have shown effectiveness in preventing dementia, but identifying high-risk groups most likely to benefit remains unclear.<h4>Methods</h4>We re-evaluated the SUPERBRAIN-MEET multidomain intervention study in mild cognitive impairment (MCI) patients, incorporating polygenic risk scores (PRS) for Alzheimer's disease and APOE ε4 status using Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) total index as the primary outcome.<h4>Results</h4>Both intervention and control groups showed cognitive improvement over 24 weeks, with greater gains in the intervention arm. Relative intervention efficacy (RIE) increased with higher genetic risk, being most pronounced among APOE ε4 carriers and individuals with high PRS. When ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-06T03:00:18.797Z","creation":"2026-05-25T03:08:00.059Z"},"accession":"S-EPMC12699802","cross_references":{"pubmed":["41388319"],"doi":["10.1186/s13195-025-01907-3"]}}