{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(1)"],"submitter":["Wang L"],"pubmed_abstract":["Background Hepatotoxicity is a significant concern for patients with colorectal cancer (CRC), potentially leading to severe complications, including death. This study aims to quantify the overall and long-term risks of chronic liver disease and cirrhosis (CLDC) death among CRC patients following surgery. Methods Data of the patients with colon cancer or rectal cancer were extracted from the Surveillance, Epidemiology, and End Results (SEER) database (1992-2021). Cumulative mortality functions, standardized mortality ratios (SMRs), and absolute excess risk (AER) were calculated to evaluate the risk of CLDC mortality. Results CRC survivors had higher CLDC mortality than the general population (colon SMR 1.76; rectal SMR 1.42). Significantly, the highest AER was recorded among individuals dia"],"journal":["Scientific reports"],"pagination":["43736"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12700856"],"repository":["biostudies-literature"],"pubmed_title":["Chronic liver disease and cirrhosis mortality following surgery for colon or rectal cancer."],"pmcid":["PMC12700856"],"pubmed_authors":["Lou X","Liu C","Xu J","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"Chronic liver disease and cirrhosis mortality following surgery for colon or rectal cancer.","description":"Background Hepatotoxicity is a significant concern for patients with colorectal cancer (CRC), potentially leading to severe complications, including death. This study aims to quantify the overall and long-term risks of chronic liver disease and cirrhosis (CLDC) death among CRC patients following surgery. Methods Data of the patients with colon cancer or rectal cancer were extracted from the Surveillance, Epidemiology, and End Results (SEER) database (1992-2021). Cumulative mortality functions, standardized mortality ratios (SMRs), and absolute excess risk (AER) were calculated to evaluate the risk of CLDC mortality. Results CRC survivors had higher CLDC mortality than the general population (colon SMR 1.76; rectal SMR 1.42). Significantly, the highest AER was recorded among individuals dia","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-05-26T20:02:00.845Z","creation":"2026-05-24T03:12:22.386Z"},"accession":"S-EPMC12700856","cross_references":{"pubmed":["41387752"],"doi":["10.1038/s41598-025-28763-3"]}}