biostudies-literatureZeng QScience and Technology Development Program of Jinan Municipal Health Commission43735https://www.ebi.ac.uk/biostudies/studies/S-EPMC12700950biostudies-literatureUnknown15(1)To construct a non-invasive and convenient early diagnostic model by integrating multidimensional clinical data and platelet (PLT) indices, and to explore the predictive value of PLT for severe Retinopathy of Prematurity (ROP). A study included premature infants admitted to our hospital from January 2020 to September 2025. According to the results of fundus screening, subjects were divided into the ROP group (n = 190) and the normal control group (n = 142). The ROP group was further categorized into mild (n = 110) and severe (n = 15) subgroups based on treatment requirements, which included platelet data corresponding to a postmenstrual age (PMA) of 30 weeks. Clinical data on parental factors, neonatal factors, and treatment factors were collected, along with PLT results from birth to PMA Scientific reportsDevelopment of a non-invasive diagnostic model for severe Retinopathy of Prematurity integrating clinical and platelet data.PMC127009502024308009Li YZeng QLv XWu DWang JLiu GfalseDevelopment of a non-invasive diagnostic model for severe Retinopathy of Prematurity integrating clinical and platelet data.To construct a non-invasive and convenient early diagnostic model by integrating multidimensional clinical data and platelet (PLT) indices, and to explore the predictive value of PLT for severe Retinopathy of Prematurity (ROP). A study included premature infants admitted to our hospital from January 2020 to September 2025. According to the results of fundus screening, subjects were divided into the ROP group (n = 190) and the normal control group (n = 142). The ROP group was further categorized into mild (n = 110) and severe (n = 15) subgroups based on treatment requirements, which included platelet data corresponding to a postmenstrual age (PMA) of 30 weeks. Clinical data on parental factors, neonatal factors, and treatment factors were collected, along with PLT results from birth to PMA 2025-01-01T00:00:00Z2025 Dec2026-06-06T02:03:32.333Z2026-05-24T03:12:19.127ZS-EPMC127009504138775510.1038/s41598-025-28293-y