{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["106(2)"],"submitter":["Moreno-Chamba B"],"funding":["Ministerio de Ciencia e Innovación","Junta de Andalucía"],"pubmed_abstract":["<h4>Background</h4>Persimmon (Diospyros kaki Thunb.) byproducts are a remarkable source of bioactive compounds, particularly carotenoids. Several studies suggest that carotenoids have beneficial effects in prevention of a large number of diseases. This study aims to highlight the effects of a persimmon carotenoid extract (PSCE) rich in β-cryptoxanthin (β-CRX, 51%) in ameliorating type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated steatotic liver disease (MASLD) in male C57BL6J mice. Animals were fed with a low-fat diet (LFD, n = 10), a LFD plus PSCE (0.8 mg kg<sup>-1</sup> body weight per day; LFD-PSCE, n = 10), or a high-fat diet (HFD, n = 20), for 6 months. At the third month, 10 random mice from the HFD group were supplemented with PSCE for the remaining 3 months (HFD-"],"journal":["Journal of the science of food and agriculture"],"pagination":["1299-1313"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12701299"],"repository":["biostudies-literature"],"pubmed_title":["Persimmon carotenoid extract rich in β-cryptoxanthin improves glucose homeostasis and reduces liver damage in high-fat-diet-induced type 2 diabetic and metabolic dysfunction-associated steatotic liver disease mice."],"pmcid":["PMC12701299"],"pubmed_authors":["Martin F","Marti N","Fernandez-Pachon MS","Berna G","Martinez-Madrid MC","Salazar-Bermeo J","Saura D","Cardenas A","Moreno-Chamba B","Escudero-Lopez B","Valero M"],"additional_accession":[]},"is_claimable":false,"name":"Persimmon carotenoid extract rich in β-cryptoxanthin improves glucose homeostasis and reduces liver damage in high-fat-diet-induced type 2 diabetic and metabolic dysfunction-associated steatotic liver disease mice.","description":"<h4>Background</h4>Persimmon (Diospyros kaki Thunb.) byproducts are a remarkable source of bioactive compounds, particularly carotenoids. Several studies suggest that carotenoids have beneficial effects in prevention of a large number of diseases. This study aims to highlight the effects of a persimmon carotenoid extract (PSCE) rich in β-cryptoxanthin (β-CRX, 51%) in ameliorating type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated steatotic liver disease (MASLD) in male C57BL6J mice. Animals were fed with a low-fat diet (LFD, n = 10), a LFD plus PSCE (0.8 mg kg<sup>-1</sup> body weight per day; LFD-PSCE, n = 10), or a high-fat diet (HFD, n = 20), for 6 months. At the third month, 10 random mice from the HFD group were supplemented with PSCE for the remaining 3 months (HFD-","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-06T02:08:32.133Z","creation":"2026-05-24T03:12:25.149Z"},"accession":"S-EPMC12701299","cross_references":{"pubmed":["41133734"],"doi":["10.1002/jsfa.70276"]}}