biostudies-literatureUnknown106(2)Moreno-Chamba BMinisterio de Ciencia e InnovaciónJunta de Andalucía<h4>Background</h4>Persimmon (Diospyros kaki Thunb.) byproducts are a remarkable source of bioactive compounds, particularly carotenoids. Several studies suggest that carotenoids have beneficial effects in prevention of a large number of diseases. This study aims to highlight the effects of a persimmon carotenoid extract (PSCE) rich in β-cryptoxanthin (β-CRX, 51%) in ameliorating type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated steatotic liver disease (MASLD) in male C57BL6J mice. Animals were fed with a low-fat diet (LFD, n = 10), a LFD plus PSCE (0.8 mg kg^-1 body weight per day; LFD-PSCE, n = 10), or a high-fat diet (HFD, n = 20), for 6 months. At the third month, 10 random mice from the HFD group were supplemented with PSCE for the remaining 3 months (HFD-Journal of the science of food and agriculture1299-1313https://www.ebi.ac.uk/biostudies/studies/S-EPMC12701299biostudies-literaturePersimmon carotenoid extract rich in β-cryptoxanthin improves glucose homeostasis and reduces liver damage in high-fat-diet-induced type 2 diabetic and metabolic dysfunction-associated steatotic liver disease mice.PMC12701299Martin FMarti NFernandez-Pachon MSBerna GMartinez-Madrid MCSalazar-Bermeo JSaura DCardenas AMoreno-Chamba BEscudero-Lopez BValero MfalsePersimmon carotenoid extract rich in β-cryptoxanthin improves glucose homeostasis and reduces liver damage in high-fat-diet-induced type 2 diabetic and metabolic dysfunction-associated steatotic liver disease mice.<h4>Background</h4>Persimmon (Diospyros kaki Thunb.) byproducts are a remarkable source of bioactive compounds, particularly carotenoids. Several studies suggest that carotenoids have beneficial effects in prevention of a large number of diseases. This study aims to highlight the effects of a persimmon carotenoid extract (PSCE) rich in β-cryptoxanthin (β-CRX, 51%) in ameliorating type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated steatotic liver disease (MASLD) in male C57BL6J mice. Animals were fed with a low-fat diet (LFD, n = 10), a LFD plus PSCE (0.8 mg kg^-1 body weight per day; LFD-PSCE, n = 10), or a high-fat diet (HFD, n = 20), for 6 months. At the third month, 10 random mice from the HFD group were supplemented with PSCE for the remaining 3 months (HFD-2026-01-01T00:00:00Z2026 Jan2026-06-06T02:08:32.133Z2026-05-24T03:12:25.149ZS-EPMC127012994113373410.1002/jsfa.70276