{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["23(1)"],"submitter":["Yang YF"],"pubmed_abstract":["<h4>Background</h4>Glycosylphosphatidylinositol transamidase (GPI-T) catalyzes the attachment of glycosylphosphatidylinositol (GPI) anchors to membrane proteins implicated in oncogenic signaling. However, the specific contribution of individual GPI-T subunits to head and neck cancer (HNC) remains unclear.<h4>Methods</h4>We first compare the expression profiles of GPI-T subunits in HNC and then integrate multi-omics analyses to assess <i>phosphatidylinositol glycan class K</i> (<i>PIGK</i>) expression, genomic alterations, function and pathway enrichment, molecular interactions, and immune associations. Clinical relevance is validated by immunohistochemistry on tissue microarray, and <i>in vitro</i> assays were conducted to assess PIGK-mediated phenotypes, regulation of <i>Family with seque"],"journal":["International journal of medical sciences"],"pagination":["161-176"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12701967"],"repository":["biostudies-literature"],"pubmed_title":["Integrative analysis identifies PIGK as an oncogenic glycosylphosphatidylinositol transamidase subunit with prognostic, immunological, and therapeutic relevance in head and neck cancer."],"pmcid":["PMC12701967"],"pubmed_authors":["Chou CY","Yang YF","Lin YH","Yu PL","Liao JB"],"additional_accession":[]},"is_claimable":false,"name":"Integrative analysis identifies PIGK as an oncogenic glycosylphosphatidylinositol transamidase subunit with prognostic, immunological, and therapeutic relevance in head and neck cancer.","description":"<h4>Background</h4>Glycosylphosphatidylinositol transamidase (GPI-T) catalyzes the attachment of glycosylphosphatidylinositol (GPI) anchors to membrane proteins implicated in oncogenic signaling. However, the specific contribution of individual GPI-T subunits to head and neck cancer (HNC) remains unclear.<h4>Methods</h4>We first compare the expression profiles of GPI-T subunits in HNC and then integrate multi-omics analyses to assess <i>phosphatidylinositol glycan class K</i> (<i>PIGK</i>) expression, genomic alterations, function and pathway enrichment, molecular interactions, and immune associations. Clinical relevance is validated by immunohistochemistry on tissue microarray, and <i>in vitro</i> assays were conducted to assess PIGK-mediated phenotypes, regulation of <i>Family with seque","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026","modification":"2026-06-06T08:58:44.592Z","creation":"2026-05-28T03:12:06.81Z"},"accession":"S-EPMC12701967","cross_references":{"pubmed":["41399371"],"doi":["10.7150/ijms.121484"]}}