{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tomar AS"],"funding":["The Eye Cancer Foundation","The Paul T. Finger Fund","The John and Myrna Daniels Charitable Trust"],"pagination":["1409-1416"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12703232"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["109(12)"],"pubmed_abstract":["<h4>Background</h4>To determine the unique clinical characteristics and treatment outcomes of diffuse infiltrating retinoblastoma (DIR).<h4>Methods</h4>This international, multicentre, registry-based retrospective case series analysed pooled data from January 2001 to December 2013, including 132 eyes from 132 patients with DIR.<h4>Results</h4>Among 2854 eyes with retinoblastoma, 132 (4.6%; 95% CI, 3.9 to 5.5) had DIR. The median age at diagnosis for DIR patients was 24 months (IQR, 15-33), with no bilateral cases of DIR. The American Joint Committee on Cancer staging showed 4.5% cT2 and 95.5% cT3 categories, with no cT1 or cT4 cases. Clinical features associated with DIR included secondary glaucoma (67%), retinal detachment (38%), diffuse vitreous seeds (37%), anterior segment involvement "],"journal":["The British journal of ophthalmology"],"pubmed_title":["Diffuse infiltrating retinoblastoma: a multicentre, international, data-sharing study."],"pmcid":["PMC12703232"],"funding_grant_id":["N/A"],"pubmed_authors":["Mallipatna A","Kivela TT","Carreras E","Yarovoy A","Brennan RC","Berry JL","Catala-Mora J","Volodin D","Esparza-Aguiar E","Tomar AS","Ushakova TL","Fandino A","Essuman VA","Moorthy S","Long QB","Sharwood P","Semenova E","Ganesan S","Yugay OV","Ramirez-Ortiz MA","Zhang C","Yam JC","Zhao J","Kotova E","Jubran R","Khetan V","Schaiquevich P","Gallie B","Burges M","Lam CP","Nummi K","Yousef YA","Yarovaya V","Polyakov VG","Wilson MW","Lau WW","AJCC OOTF","Renner LA","Finger PT","Chantada G","Correa-Llano G"],"additional_accession":[]},"is_claimable":false,"name":"Diffuse infiltrating retinoblastoma: a multicentre, international, data-sharing study.","description":"<h4>Background</h4>To determine the unique clinical characteristics and treatment outcomes of diffuse infiltrating retinoblastoma (DIR).<h4>Methods</h4>This international, multicentre, registry-based retrospective case series analysed pooled data from January 2001 to December 2013, including 132 eyes from 132 patients with DIR.<h4>Results</h4>Among 2854 eyes with retinoblastoma, 132 (4.6%; 95% CI, 3.9 to 5.5) had DIR. The median age at diagnosis for DIR patients was 24 months (IQR, 15-33), with no bilateral cases of DIR. The American Joint Committee on Cancer staging showed 4.5% cT2 and 95.5% cT3 categories, with no cT1 or cT4 cases. Clinical features associated with DIR included secondary glaucoma (67%), retinal detachment (38%), diffuse vitreous seeds (37%), anterior segment involvement ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-06T02:24:51.907Z","creation":"2026-05-24T03:12:50.928Z"},"accession":"S-EPMC12703232","cross_references":{"pubmed":["40738737"],"doi":["10.1136/bjo-2024-326778"]}}