biostudies-literatureTomar ASThe Eye Cancer FoundationThe Paul T. Finger FundThe John and Myrna Daniels Charitable Trust1409-1416https://www.ebi.ac.uk/biostudies/studies/S-EPMC12703232biostudies-literatureUnknown109(12)<h4>Background</h4>To determine the unique clinical characteristics and treatment outcomes of diffuse infiltrating retinoblastoma (DIR).<h4>Methods</h4>This international, multicentre, registry-based retrospective case series analysed pooled data from January 2001 to December 2013, including 132 eyes from 132 patients with DIR.<h4>Results</h4>Among 2854 eyes with retinoblastoma, 132 (4.6%; 95% CI, 3.9 to 5.5) had DIR. The median age at diagnosis for DIR patients was 24 months (IQR, 15-33), with no bilateral cases of DIR. The American Joint Committee on Cancer staging showed 4.5% cT2 and 95.5% cT3 categories, with no cT1 or cT4 cases. Clinical features associated with DIR included secondary glaucoma (67%), retinal detachment (38%), diffuse vitreous seeds (37%), anterior segment involvement The British journal of ophthalmologyDiffuse infiltrating retinoblastoma: a multicentre, international, data-sharing study.PMC12703232N/AMallipatna AKivela TTCarreras EYarovoy ABrennan RCBerry JLCatala-Mora JVolodin DEsparza-Aguiar ETomar ASUshakova TLFandino AEssuman VAMoorthy SLong QBSharwood PSemenova EGanesan SYugay OVRamirez-Ortiz MAZhang CYam JCZhao JKotova EJubran RKhetan VSchaiquevich PGallie BBurges MLam CPNummi KYousef YAYarovaya VPolyakov VGWilson MWLau WWAJCC OOTFRenner LAFinger PTChantada GCorrea-Llano GfalseDiffuse infiltrating retinoblastoma: a multicentre, international, data-sharing study.<h4>Background</h4>To determine the unique clinical characteristics and treatment outcomes of diffuse infiltrating retinoblastoma (DIR).<h4>Methods</h4>This international, multicentre, registry-based retrospective case series analysed pooled data from January 2001 to December 2013, including 132 eyes from 132 patients with DIR.<h4>Results</h4>Among 2854 eyes with retinoblastoma, 132 (4.6%; 95% CI, 3.9 to 5.5) had DIR. The median age at diagnosis for DIR patients was 24 months (IQR, 15-33), with no bilateral cases of DIR. The American Joint Committee on Cancer staging showed 4.5% cT2 and 95.5% cT3 categories, with no cT1 or cT4 cases. Clinical features associated with DIR included secondary glaucoma (67%), retinal detachment (38%), diffuse vitreous seeds (37%), anterior segment involvement 2025-01-01T00:00:00Z2025 Nov2026-06-06T02:24:51.907Z2026-05-24T03:12:50.928ZS-EPMC127032324073873710.1136/bjo-2024-326778