{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["74(12)"],"submitter":["Lucas-Ruiz F"],"pubmed_abstract":["<h4>Background</h4>Liver transplantation (LT) remains hampered by post-transplant complications. While gut microbiota dysbiosis has been linked to transplant outcomes, the role of the intrahepatic graft's native microbiota remains unexplored.<h4>Objective</h4>To characterise the microbial profile detected in organ preservation solution (OPS) and determine whether specific microbial taxa are associated with short-term clinical outcomes, and to develop predictive models for risk stratification.<h4>Design</h4>We analysed the OPS microbiota-based metataxonomic signature from 110 LT donors (discovery cohort) and an independent validation cohort (n=29) using 16S rRNA sequencing. Microbial DNA signatures associated with clinical outcomes were identified through MaAsLin2-adjusted models, and relev"],"journal":["Gut"],"pagination":["2058-2069"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12703288"],"repository":["biostudies-literature"],"pubmed_title":["Intrahepatic donor microbiota-based metataxonomic signature detected in organ preservation solution enables prediction of short-term liver transplant outcomes."],"pmcid":["PMC12703288"],"pubmed_authors":["Alconchel F","Rios-Zambudio A","Cascales P","Ramirez P","Pelegrin P","Pons JA","Vidal-Correoso D","de la Torre-Alamo MM","Lopez-Lopez V","Jover-Aguilar M","Mateo SV","Baroja-Mazo A","Lucas-Ruiz F","Martinez-Alarcon L"],"additional_accession":[]},"is_claimable":false,"name":"Intrahepatic donor microbiota-based metataxonomic signature detected in organ preservation solution enables prediction of short-term liver transplant outcomes.","description":"<h4>Background</h4>Liver transplantation (LT) remains hampered by post-transplant complications. While gut microbiota dysbiosis has been linked to transplant outcomes, the role of the intrahepatic graft's native microbiota remains unexplored.<h4>Objective</h4>To characterise the microbial profile detected in organ preservation solution (OPS) and determine whether specific microbial taxa are associated with short-term clinical outcomes, and to develop predictive models for risk stratification.<h4>Design</h4>We analysed the OPS microbiota-based metataxonomic signature from 110 LT donors (discovery cohort) and an independent validation cohort (n=29) using 16S rRNA sequencing. Microbial DNA signatures associated with clinical outcomes were identified through MaAsLin2-adjusted models, and relev","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-06-06T03:44:38.971Z","creation":"2026-05-25T03:11:21.925Z"},"accession":"S-EPMC12703288","cross_references":{"pubmed":["40803752"],"doi":["10.1136/gutjnl-2025-335986"]}}