biostudies-literatureBaysari MTNational Health and Medical Research Council788-797https://www.ebi.ac.uk/biostudies/studies/S-EPMC12703349biostudies-literatureUnknown34(12)<h4>Background</h4>Drug-drug interaction (DDI) alerts target the co-prescription of two potentially interacting medications and are a frequent feature of electronic medical records (EMRs). There have been few controlled studies evaluating the effectiveness of DDI alerts. This study aimed to determine the impact of DDI alerts on rates of DDIs and on associated patient harms.<h4>Methods</h4>Quasi-experimental controlled pre-post study in five Australian hospitals. Three hospitals acted as control hospitals (EMR with no DDI alerts) and two as intervention (EMR with DDI alerts). Only DDI alerts at the highest severity level (defined as 'major contraindicated') were switched on at intervention hospitals. These alerts were not tailored to clinical context (ie, patient, drug). A total of 2078 patBMJ quality & safetyEffectiveness of computerised alerts to reduce drug-drug interactions (DDIs) and DDI-related harm in hospitalised patients: a quasi-experimental controlled pre-post study.PMC12703349APP1134824Stanceski KGrant JQuirk RLi LHargreaves ASalem AADoherty PMekhail KZSHilmer SNDeidun DAryal NDay ROVan Dort BAMoran MBaker JWestbrook JIZheng WYBaysari MTFarrow LfalseEffectiveness of computerised alerts to reduce drug-drug interactions (DDIs) and DDI-related harm in hospitalised patients: a quasi-experimental controlled pre-post study.<h4>Background</h4>Drug-drug interaction (DDI) alerts target the co-prescription of two potentially interacting medications and are a frequent feature of electronic medical records (EMRs). There have been few controlled studies evaluating the effectiveness of DDI alerts. This study aimed to determine the impact of DDI alerts on rates of DDIs and on associated patient harms.<h4>Methods</h4>Quasi-experimental controlled pre-post study in five Australian hospitals. Three hospitals acted as control hospitals (EMR with no DDI alerts) and two as intervention (EMR with DDI alerts). Only DDI alerts at the highest severity level (defined as 'major contraindicated') were switched on at intervention hospitals. These alerts were not tailored to clinical context (ie, patient, drug). A total of 2078 pat2025-01-01T00:00:00Z2025 Nov2026-06-07T05:02:41.628Z2026-06-07T03:07:09.731ZS-EPMC127033494035026510.1136/bmjqs-2024-018243