{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Savani RH"],"funding":["National Institute of Diabetes and Digestive and Kidney Diseases","Whitehall Foundation","National Institutes of Health","Robert Wood Johnson Foundation"],"pagination":["114070"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12704261"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(12)"],"pubmed_abstract":["Energy homeostasis is tightly regulated to ensure metabolic health in uncertain environments. Neurons expressing the glucagon-like peptide-1 receptor (GLP-1R) contribute to maintaining body weight, but how their activity is regulated according to energy state remains unclear. Here, we investigated the function and cellular dynamics of GLP-1R-expressing neurons of the paraventricular hypothalamus (PVH<sup>GLP-1R</sup>) during food consumption, providing strong evidence of their ability to bidirectionally control feeding. Elevating intracellular signaling through 3',5'-cyclic adenosine monophosphate (cAMP), the major pathway downstream of GLP-1R, suppressed feeding. Using two-photon calcium imaging, we observed heterogeneous single-cell responses to ingestion that occurred regardless of ener"],"journal":["iScience"],"pubmed_title":["Individual paraventricular hypothalamic GLP-1R neurons track ingestion across energy states."],"pmcid":["PMC12704261"],"funding_grant_id":["74260","R01DK136641","R01DK131452","2022-12-051"],"pubmed_authors":["Lu Y","Savani RH","Yang M","Le T","Pang ZP","Rossi MA","Wang L","Park E"],"additional_accession":[]},"is_claimable":false,"name":"Individual paraventricular hypothalamic GLP-1R neurons track ingestion across energy states.","description":"Energy homeostasis is tightly regulated to ensure metabolic health in uncertain environments. Neurons expressing the glucagon-like peptide-1 receptor (GLP-1R) contribute to maintaining body weight, but how their activity is regulated according to energy state remains unclear. Here, we investigated the function and cellular dynamics of GLP-1R-expressing neurons of the paraventricular hypothalamus (PVH<sup>GLP-1R</sup>) during food consumption, providing strong evidence of their ability to bidirectionally control feeding. Elevating intracellular signaling through 3',5'-cyclic adenosine monophosphate (cAMP), the major pathway downstream of GLP-1R, suppressed feeding. Using two-photon calcium imaging, we observed heterogeneous single-cell responses to ingestion that occurred regardless of ener","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-07-15T06:34:04.042Z","creation":"2026-06-30T03:20:42.048Z"},"accession":"S-EPMC12704261","cross_references":{"pubmed":["41403831"],"doi":["10.1016/j.isci.2025.114070"]}}