{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pearl MH"],"funding":["National Institute of Allergy and Infectious Diseases","National Center for Advancing Translational Sciences","National Kidney Foundation","Koch Foundation","NCATS NIH HHS","American Society of Nephrology","NIDDK NIH HHS","NIAID NIH HHS","University of California Los Angeles Clinical and Translational Science Institute","National Institutes of Health","University of California, Los Angeles"],"pagination":["2329-2344"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12704516"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(11)"],"pubmed_abstract":["Activating antibodies to angiotensin II type 1 receptor (AT1R) and endothelin type A receptor (ETAR) have been associated with rejection, allograft loss, decline in allograft function, and development of human leukocyte antigen donor-specific antibodies in kidney transplantation. Understanding immune dysregulation and inflammatory signatures associated with these antibodies is important for generating targeted investigations of pathogenesis. We investigated a panel of 38 cytokines in a multicenter cohort of 133 pediatric kidney transplant recipients with 1 to 2 years of follow up to further elucidate AT1R and ETAR-Ab-associated inflammatory signatures. Pretransplant and posttransplant blood samples (n = 483) were tested for AT1R-Ab, ETAR-Ab, and 38 cytokines. The relationship between AT1R "],"journal":["American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons"],"pubmed_title":["Antibodies to angiotensin II type 1 receptor and endothelin type A receptor are associated with cytokine production enriched for type 2 immune response and antibody production in pediatric kidney transplant recipients."],"pmcid":["PMC12704516"],"funding_grant_id":["U19 AI172713","UL1TR001881","K23 AI139335","5K23AI139335","R01 AI173050","UL1 TR001881","R01 AI135201","T32 DK104687","U01 AI135947","R01AI135201","5U19AI172713","U01 AI077821","R01AI173050","PO1 AI120944"],"pubmed_authors":["Ettenger R","Pearl MH","Tsai-Chambers E","Nikfarjam N","Chen L","Grogan T","Reed EF","Garro R","Kirk AD","Grimm PC","Fan C"],"additional_accession":[]},"is_claimable":false,"name":"Antibodies to angiotensin II type 1 receptor and endothelin type A receptor are associated with cytokine production enriched for type 2 immune response and antibody production in pediatric kidney transplant recipients.","description":"Activating antibodies to angiotensin II type 1 receptor (AT1R) and endothelin type A receptor (ETAR) have been associated with rejection, allograft loss, decline in allograft function, and development of human leukocyte antigen donor-specific antibodies in kidney transplantation. Understanding immune dysregulation and inflammatory signatures associated with these antibodies is important for generating targeted investigations of pathogenesis. We investigated a panel of 38 cytokines in a multicenter cohort of 133 pediatric kidney transplant recipients with 1 to 2 years of follow up to further elucidate AT1R and ETAR-Ab-associated inflammatory signatures. Pretransplant and posttransplant blood samples (n = 483) were tested for AT1R-Ab, ETAR-Ab, and 38 cytokines. The relationship between AT1R ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-07-15T13:17:33.415Z","creation":"2026-07-05T03:08:22.534Z"},"accession":"S-EPMC12704516","cross_references":{"pubmed":["40774357"],"doi":["10.1016/j.ajt.2025.07.2486"]}}