biostudies-literatureUnknownKawles ANIA NIH HHSNIDCD NIH HHSNINDS NIH HHS<h4>Objective</h4>Frontotemporal lobar degenerations (FTLD)-TDP type C (TDP-C) is distinguished from other FTLD-TDP subtypes by 3 unique features: (1) invariable onset in the anterior temporal lobe (ATL), (2) phosphorylated TDP-43 (pTDP) neurites in cortex, and (3) colocalization of all pTDP deposits with annexin A11 (ANXA11). This article provides a whole-brain anatomical account of TDP-C disease progression in relation to clinical, imaging, and neuropathologic patterns.<h4>Methods</h4>Thirty-two cases with TDP-C were studied, including neuropathologic findings and longitudinal magnetic resonance imaging. In 6 of these cases, cortical and subcortical areas were analyzed using whole hemisphere sections. Five control cases were used for comparison.<h4>Results</h4>Progression was reconstructAnnals of neurologyhttps://www.ebi.ac.uk/biostudies/studies/S-EPMC12704552biostudies-literatureAnatomical Progression of Neuropathology in FTLD-TDP Type C and Linkage to Annexin A11.PMC12704552R56 AG075600R01 AG091388R01 AG077444P30 AG072977F31 AG094137T32 AG020506R01 DC008552R01 NS075075P30 AG013854Barbieri ENelson CGefen TGeula CMesulam MMCastellani RKawles AAyala IfalseAnatomical Progression of Neuropathology in FTLD-TDP Type C and Linkage to Annexin A11.<h4>Objective</h4>Frontotemporal lobar degenerations (FTLD)-TDP type C (TDP-C) is distinguished from other FTLD-TDP subtypes by 3 unique features: (1) invariable onset in the anterior temporal lobe (ATL), (2) phosphorylated TDP-43 (pTDP) neurites in cortex, and (3) colocalization of all pTDP deposits with annexin A11 (ANXA11). This article provides a whole-brain anatomical account of TDP-C disease progression in relation to clinical, imaging, and neuropathologic patterns.<h4>Methods</h4>Thirty-two cases with TDP-C were studied, including neuropathologic findings and longitudinal magnetic resonance imaging. In 6 of these cases, cortical and subcortical areas were analyzed using whole hemisphere sections. Five control cases were used for comparison.<h4>Results</h4>Progression was reconstruct2025-01-01T00:00:00Z2025 Nov2026-06-06T03:42:26.875Z2026-05-25T03:08:09.284ZS-EPMC127045524129407610.1002/ana.78095