biostudies-literatureUnknown11(8)Fumagalli SMenarini Group<h4>Aims</h4>Ranolazine (Ran) is an anti-anginal drug inhibiting late sodium current, an action possibly hindering arrhythmias onset. Indeed, some evidence supports the anti-arrhythmic effects of Ran. The aim of this study, which evaluated Italian patients with chronic coronary syndrome (CCS), was to investigate whether Ran, as an add-on therapy, was associated with a lower incidence of atrial fibrillation (AF) compared with no-Ran prescription (No-Ran).<h4>Methods and results</h4>The original population (N = 6.1 million) derived from the databases of the Italian National Health System; information concerned hospitalizations with the related diagnoses, drug therapy, follow-up clinical events and visits. Patients hospitalized between 2011 and 2020 for any cause and discharged with an ICD-9-European heart journal. Cardiovascular pharmacotherapy674-681https://www.ebi.ac.uk/biostudies/studies/S-EPMC12705168biostudies-literatureRanolazine in patients with chronic coronary syndromes: real-world data provide new evidence on the antiarrhythmic properties of the drug.PMC12705168Cerbai EFumagalli SSpanalatte GFumagalli CSantamaria ETariello AMazzoni SCagnoni CDovizio MMarchionni NDegli Esposti LfalseRanolazine in patients with chronic coronary syndromes: real-world data provide new evidence on the antiarrhythmic properties of the drug.<h4>Aims</h4>Ranolazine (Ran) is an anti-anginal drug inhibiting late sodium current, an action possibly hindering arrhythmias onset. Indeed, some evidence supports the anti-arrhythmic effects of Ran. The aim of this study, which evaluated Italian patients with chronic coronary syndrome (CCS), was to investigate whether Ran, as an add-on therapy, was associated with a lower incidence of atrial fibrillation (AF) compared with no-Ran prescription (No-Ran).<h4>Methods and results</h4>The original population (N = 6.1 million) derived from the databases of the Italian National Health System; information concerned hospitalizations with the related diagnoses, drug therapy, follow-up clinical events and visits. Patients hospitalized between 2011 and 2020 for any cause and discharged with an ICD-9-2025-01-01T00:00:00Z2025 Dec2026-06-06T03:46:12.171Z2026-05-25T03:11:25.895ZS-EPMC127051684102698610.1093/ehjcvp/pvaf074