biostudies-literatureUnknown15(58)Tran LVH<i>Nelumbo nucifera</i> Gaertn. has been used as a traditional medicine and food. To date, many unknown constituents have been discovered. Most of the researches on secondary metabolites and their pharmacological properties focus on alkaloid derivatives. In this study, a novel pyrrole terpenoid hydrid, lotusin A (1), and five reported substances, cholestanol (2), stigmast-4-en-3-one (3), quercetin (4), isorhamnetin (5), and norartocarpetin (6), were isolated from the methanol extract of the roots of <i>N. nucifera</i> Gaertn. The structures (1-6) were identified <i>via</i> spectroscopic analyses of NMR (1D and 2D), HR-ESIMS, and comparisons with those previously reported in the literature. Compound 1, a pyrrole terpenoid hydrid, is a unique isolate from plant natural products. Compounds 1 RSC advances50103-50110https://www.ebi.ac.uk/biostudies/studies/S-EPMC12705226biostudies-literatureLotusin A: a novel pyrrole terpenoid hydrid from lotus roots (<i>Nelumbo nucifera</i> Gaertn.).PMC12705226Hoang Long TTran LVHLa VHPhan TTTon That QLe DTVo HCThai KMThi Thuy Duong NLe MTLe QTNguyen MCTran LTran HNKNguyen TDLHoang LTfalseLotusin A: a novel pyrrole terpenoid hydrid from lotus roots (<i>Nelumbo nucifera</i> Gaertn.).<i>Nelumbo nucifera</i> Gaertn. has been used as a traditional medicine and food. To date, many unknown constituents have been discovered. Most of the researches on secondary metabolites and their pharmacological properties focus on alkaloid derivatives. In this study, a novel pyrrole terpenoid hydrid, lotusin A (1), and five reported substances, cholestanol (2), stigmast-4-en-3-one (3), quercetin (4), isorhamnetin (5), and norartocarpetin (6), were isolated from the methanol extract of the roots of <i>N. nucifera</i> Gaertn. The structures (1-6) were identified <i>via</i> spectroscopic analyses of NMR (1D and 2D), HR-ESIMS, and comparisons with those previously reported in the literature. Compound 1, a pyrrole terpenoid hydrid, is a unique isolate from plant natural products. Compounds 1 2025-01-01T00:00:00Z2025 Dec2026-06-13T04:47:49.491Z2026-06-13T03:08:56.51ZS-EPMC127052264140367210.1039/d5ra05354d