biostudies-literatureUnknown40(6)Edwards GAustralian Government Research Training Program ScholarshipDespite their conceptual similarities and importance for effective health management, the relationship between health literacy and eHealth literacy remains poorly understood. This systematic review investigated the statistical association between health literacy and eHealth literacy in adults, along with study-level moderators and biopsychosocial correlates. CINAHL, Embase, Emcare, PubMed, ProQuest, PsycINFO, and Web of Science were searched until January 2025. Methodological reporting quality (QualSyst Checklist) was assessed and between-study heterogeneity explored using random and mixed-effects modeling. Twenty-three observational studies (N = 25 505 participants), all characterized by high methodological quality, were included. A weak positive relationship between overall health literaHealth promotion internationaldaaf217https://www.ebi.ac.uk/biostudies/studies/S-EPMC12705269biostudies-literatureExamining the relationship between health literacy and eHealth literacy in adult populations: a systematic review and meta-analysis.PMC12705269Oxlad MEdwards GDorstyn DfalseExamining the relationship between health literacy and eHealth literacy in adult populations: a systematic review and meta-analysis.Despite their conceptual similarities and importance for effective health management, the relationship between health literacy and eHealth literacy remains poorly understood. This systematic review investigated the statistical association between health literacy and eHealth literacy in adults, along with study-level moderators and biopsychosocial correlates. CINAHL, Embase, Emcare, PubMed, ProQuest, PsycINFO, and Web of Science were searched until January 2025. Methodological reporting quality (QualSyst Checklist) was assessed and between-study heterogeneity explored using random and mixed-effects modeling. Twenty-three observational studies (N = 25 505 participants), all characterized by high methodological quality, were included. A weak positive relationship between overall health litera2025-01-01T00:00:00Z2025 Oct2026-06-07T05:11:11.381Z2026-06-07T03:06:49.267ZS-EPMC127052694139831510.1093/heapro/daaf217